Introduction
Endotoxin plays a role in the development of Gram-negative bacterial sepsis. In Japan, polymyxin B-attached fibers (PMX-B) are used clinically as an endotoxin absorption therapy to neutralize the biological activity of lipid A, the immunomodulatory center of lipopolysaccharide (LPS) endotoxin. Because hemodynamic improvement is not seen in all cases, it cannot be assumed that this therapy will be effective against all cases of sepsis.