Plasma cell-free DNA at admission according to baseline PaO
-ratio based on SOFA cut-offs. Data are presented as median values (lines) with 25th and 75th percentiles (boxes) and 5th and 95th percentiles (whiskers). Sample A obtained at admission. Comparison between groups by Kruskal-Wallis test (P < 0.001). Post hoc analyses between groups by Mann-Whitney test (P < 0.01 considered significant due to multiple comparisons). GE, genome equivalents; NS, non-significant; SOFA, Sequential Organ Failure Assessment.