O2 delivery and CO2 production during cardiopulmonary bypass as determinants of acute kidney injury: time for a goal-directed perfusion management?

Table 3 Multivariable stepwise forward logistic regression analysis for acute kidney injury and any damage-independent predictors^a

	Factor
Acute kidney injury severity	β coefficient	Odds ratio (95% CI)	P value
Acute kidney injury stage 2
Model 1
EuroSCORE	0.034	1.035 (1.016 to 1.054)	0.001
CPB duration (minutes)	0.008	1.008 (1.002 to 1.015)	0.012
Nadir DO₂ < 262 mL/minute/m²	1.135	3.111 (1.531 to 6.319)	0.002
Model 2
EuroSCORE	0.035	1.036 (1.017 to 1.055)	0.001
CPB duration (minutes)	0.008	1.008 (1.002 to 1.014)	0.007
Nadir DO₂/VCO₂ ratio < 5.3	1.062	2.893 (1.452 to 5.763)	0.003
Any acute kidney injury
EuroSCORE	0.026	1.026 (1.008 to 1.045)	0.005
CPB duration (minutes)	0.009	1.009 (1.003 to 1.015)	0.004
Nadir DO₂ < 262 mL/minute/m²	0.767	2.154 (1.205 to 3.849)	0.010

^aCPB: cardiopulmonary bypass; CI: confidence interval; DO₂: oxygen delivery; VCO₂: carbon dioxide production.

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