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Table 4 Probability of target time the concentration is four times the MIC attainment for various MICs

From: Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy

MIC (μg/ml)

Target concentrations (μg/ml)

MEM

(n= 22)

FEP

(n= 11)

CAZ

(n= 15)

TZP

(n= 21)

32

128

0

0

0

3 (14)

16

64

0

0

0

15 (71)

8

32

0

0

8 (53)

19 (90)

4

16

9 (41)

7 (63)

13 (87)

21 (100)

2

8

18 (81)

10 (90)

15 (100)

21 (100)

1

4

22 (100)

11 (100)

15 (100)

21 (100)

0.5

2

22 (100)

11 (100)

15 (100)

21 (100)

  1. Data expressed as numbers of series (percentages). Data in bold show targets attained in at least 90% of patients for the indicated minimum inhibitory concentrations (MICs) corresponding to European Committee on Antimicrobial Susceptibility Testing clinical breakpoints for Pseudomonas aeruginosa. MEM, meropenem; FEP, cefepime; CAZ, ceftazidime; TZP, piperacillin-tazobactam.