Impact of timing of renal replacement therapy initiation on outcome of septic acute kidney injury

Table 2 Independent predictors of in-hospital mortality obtained using the Cox proportional hazards model

Variables	Unadjusted (model 1)			Propensity score adjusted (model 2)
	HR	95% CI	P -value	HR	95% CI	P -value
Post-operative, yes	0.631	0.478 - 0.832	0.0011
Pre-RRT CVP (mmHg)	1.030	1.006 - 1.055	0.0140
Pre-RRT DBP (mmHg)	0.987	0.977 - 0.997	0.0089	0.987	0.977 - 0.997	0.013
Pre-RRT GCS scores	0.929	0.898 - 0.962	< 0.001	0.923	0.890 - 0.958	< 0.001
Pre-RRT lactate (mM)	1.086	1.048 - 1.124	< 0.001	1.073	1.034 - 1.113	< 0.001
SOFA score on ICU admission	0.941	0.907 - 0.977	0.0015	0.934	0.900 - 0.970	< 0.001
SOFA score pre-RRT	1.068	1.019 - 1.120	0.0058	1.104	1.051 - 1.160	< 0.001
Propensity scores	-	-	-	0.085	0.027 - 0.268	0.085

95% CI: 95% confidence interval; CVP: central venous pressure; DBP: diastolic blood pressure; GCS: Glasgow Coma Scale; HR: hazard ratio; RRT: renal replacement therapy; SOFA: Sequential Organ Failure Assessment.

ISSN: 1364-8535