Figure 4
From: Clinical Review: Gene-based therapies for ALI/ARDS: where are we now?
Gene-based therapies may be combined with stem cells to enhance their effect. Representative histologic images of lung sections demonstrate that modification of mesenchymal stem/stromal cells (MSCs) to overexpress angiopoeitin-1 (LPS/MSCs-pANGPT1) enhanced its efficacy in attenuating endotoxin-induced lung injury (LPS/Saline) compared with MSCs alone (LPS/MSCs) or MSCs overexpressing a nonfunctional gene (LPS/MSCs-pFLAG). Reproduced with permission from The Public Library of Science [39].