Figure 2

Adenovirus-mediated gene transfer enhances surfactant production, improves lung function and confers resistance to infection. Intratracheal delivery of adenovirus encoding a modified surfactant enzyme enhances lung production of surfactant, and (a) attenuated the decrement in lung elastance and (b) increased the survival time in mice infected with Pseudomonas aeruginosa. PEEP, positive end-expiratory pressure. Reproduced with permission from The Nature Publishing Group [49].