Skip to main content

Lactate and base deficit are predictors of mortality in critically ill patients with cancer

Objective

Cancer patients frequently require admission to the intensive care unit (ICU); however, there are few data regarding predictive factors for mortality. The aim of this study was to evaluate whether arterial lactate or standard base deficit (SBD) on admission and after 24 hours can predict ICU and hospital mortality for patients with cancer.

Methods

We evaluated 1,129 patients with severe sepsis, septic shock, or postoperative after high-risk surgery. Lactate and SBD collected at admission and after 24 hours were compared between survivors and nonsurvivors. We evaluated whether arterial lactate and SBD are independent predictors of ICU and hospital mortality.

Results

There were 854 hospital survivors (76.5%). Twenty-four-hour lactate >1.9 mmol/l (OR = 4.02, CI = 2.7 to 5.97) and SBD <-2.3 (OR = 2.4, CI = 1.64 to 3.52) were independent predictors of ICU mortality. Twenty-four-hour lactate >1.9 mmol/l (HR = 2.63, CI = 1.99 to 3.47) and 24-hour SBD <-2.3 mmol/l (HR = 1.74, CI = 1.33 to 2.27) were independent predictors of hospital death.

Conclusion

Our findings suggest that lactate and SBD measurement should be included in the routine assessment of patients with cancer admitted to the ICU. These markers may be useful in the adequate allocation of resources in this population.

Author information

Affiliations

Authors

Corresponding author

Correspondence to LA Hajjar.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Hajjar, L., Vincent, J., Galas, F. et al. Lactate and base deficit are predictors of mortality in critically ill patients with cancer. Crit Care 15, P18 (2011). https://doi.org/10.1186/cc10166

Download citation

Keywords

  • Public Health
  • Cancer Patient
  • Lactate
  • Intensive Care Unit
  • Independent Predictor