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Table 3 Data of the various substrates and variables measured during nitric oxide (NO) inhalation

From: Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

 

Baseline

NO inhalation

P value

ANP (ng/l)

   

   Arterial

91 ± 22

86 ± 21

NS

   Mixed venous

90 ± 22

85 ± 21

NS

Nitrate (μmol/l)

   

   Arterial

25 ± 5

29.5 ± 3.1

NS

   Mixed venous

30 ± 9

24.4 ± 3.8

NS

cGMP (nmol/l)

   

   Arterial

13 ± 5

21 ± 7

< 0.05

   Mixed venous

12 ± 5

21 ± 7

< 0.02

Cardiac index (l/min/m2)

4.4 ± 0.4

4.4 ± 0.4

NS

MAP (mmHg)

79 ± 4

80 ± 4

NS

MPAP (mmHg)

26.0 ± 1.9

23.9 ± 1.7

0.003

PAWP (mmHg)

10.3 ± 1.3

10.3 ± 1.3

NS

CVP (mmHg)

8.2 ± 1.2

7.3 ± 1.1

< 0.02

PVRI (dyne s/cm5/m2)

314 ± 37

273 ± 32

0.015

ITBVI (ml/m2)

907 ± 48

915 ± 55

NS

PBVI (ml/m2)

196 ± 20

186 ± 27

NS

RVEDVI (ml/m2)

157 ± 11

149 ± 10

NS

EVLWI (ml/kg)

   

   Total group

18.4 ± 1.9

17.1 ± 1.6

0.14

   Nonresponders

20.6 ± 3.5

19.8 ± 3.0

NS

   Responders

16.2 ± 1.7

14.5 ± 0.9

0.15

PaO2/FiO2 (kPa)

17.7 ± 1.4

19.7 ± 1.1

0.07

A-a gradient (kPa)

41.9 ± 3.9

40.4 ± 3.6

< 0.05

Qs/Qt (%)

35.7 ± 2.0

32.8 ± 2.7

0.11

  1. NS, P > 0.2. The exact P values were established by a paired t test. The other variables were not normally distributed, and these were tested by the Wilcoxon signed-rank test. ANP, Atrial natriuretic peptide; cGMP, guanosine 3',5'-cyclic monophosphate; MAP, mean arterial pressure; MPAP, mean pulmonary artery pressure; PAWP, pulmonary artery wedge pressure; CVP, central venous pressure; PVRI, pulmonary vascular resistance index; ITBVI, intrathoracic blood volume index; PBVI, pulmonary blood volume index; RVEDVI, right ventricular end-diastolic volume index; EVLWI, extravascular lung water index; A-A, alveolar-arterial gradient.
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Critical Care

ISSN: 1364-8535