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Table 2 Data of the various substrates and variables measured during atrial natriuretic peptide (ANP) infusion

From: Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

 

Baseline

ANP infusion

P value

ANP (ng/l)

   

   Arterial

97 ± 23

109 ± 27

NS

   Mixed venous

86 ± 21

123 ± 33

< 0.05

Nitrate (μmol/l)

   

   Arterial

33 ± 8

28 ± 6

NS

   Mixed venous

30 ± 6

31 ± 6

NS

cGMP (nmol/l)

   

   Arterial

12 ± 4

16 ± 5

NS

   Mixed venous

11 ± 4

15 ± 5

< 0.01

Cardiac index (l/min/m2)

4.3 ± 0.4

4.2 ± 0.4

0.08

MAP (mmHg)

76 ± 3

78 ± 4

NS

MPAP (mmHg)

25.0 ± 1.9

25.1 ± 2.1

NS

PAWP (mmHg)

9.4 ± 1.2

10.0 ± 1.4

NS

CVP (mmHg)

8.1 ± 1.3

7.5 ± 1.2

NS

PVRI (dyne s/cm5/m2)

314 ± 36

305 ± 32

NS

ITBVI (ml/m2)

882 ± 39

925 ± 66

NS

PBVI (ml/m2)

184 ± 20

165 ± 27

NS

RVEDVI (ml/m2)

149 ± 8

150 ± 10

NS

EVLWI (ml/kg)

20.5 ± 1.7

21.3 ± 2.3

NS

PaO2/FiO2 (kPa)

18.0 ± 1.1

18.2 ± 1.5

NS

A-a gradient (kPa)

41.6 ± 3.8

41.8 ± 4.1

NS

Qs/Qt (%)

33.1 ± 2.0

34.7 ± 2.1

NS

  1. NS, P > 0.2. The exact P values were established by a paired t test. The other variables were not normally distributed, and these were tested by the Wilcoxon signed-rank test. cGMP, Guanosine 3',5'-cyclic monophosphate; MAP, mean arterial pressure; MPAP, mean pulmonary artery pressure; PAWP, pulmonary artery wedge pressure; CVP, central venous pressure; PVRI, pulmonary vascular resistance index; ITBVI, intrathoracic blood volume index; PBVI, pulmonary blood volume index; RVEDVI, right ventricular end-diastolic volume index; EVLWI, extravascular lung water index; A-A, alveolar-arterial gradient.
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Critical Care

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