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Table 2 Biochemical changes during the seven-day observational period

From: Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study

  Day 0 Day 1 Day 2 Day 3 Day 7
25(OH)D (ng/ml)      
   Placebo group 14.1 15.3* 15.0* 14.5* 13.7*
   Vitamin D group 13.1 20.5*§ 33.1*§ 35.1*§ 38.2*§
1,25(OH)2D (pmol/l)      
   Placebo group 50.6 36.3* 36.6 47.1 67.0
   Vitamin D group 68.6 89.5*§ 175.2*§ 170.8*§ 114.2
PTH (pg/ml)      
   Placebo group 91.3 72.0 79.0 75.7 71.7
   Vitamin D group 73.7 65.1 77.3 100.4 52.0
Ionized serum calcium (mmol/l)     
   Placebo group 1.03 - - 1.05 1.14§
   Vitamin D group 1.09 - - 1.11 1.14§
Total serum calcium (mmol/l)      
   Placebo group 2.03 2.02 1.98 2.02 2.13§
   Vitamin D group 2.05 2.05 2.09 2.12 2.20§
Serum phosphorus (mmol/l)      
   Placebo group 1.57* 1.34 1.49* 1.51* 1.22
   Vitamin D group 1.01* 1.20 1.08* 1.07* 1.17
Triglycerides (mg/dl)      
   Placebo group 111 126 - - 116
   Vitamin D group 180 175 - - 178
NTproBNP (pg/ml)      
   Placebo group 2100 - - - 2120
   Vitamin D group 3089 - - - 3117
Urinary calcium/creatinine ratio (mmol/mmol)    
   Placebo group 0.38 0.24 0.14 0.15 0.41
   Vitamin D group 0.38 0.19 0.27 0.28 0.27
  1. 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin D, NTproBNP, N-terminal prohormone brain natriuretic peptide; PTH, parathyroid hormone.
  2. §, P < 0.05 for intra-group comparisons (calculated in relation to baseline values) and *, P < 0.05 for between-group comparisons.