Skip to main content

Table 2 Terminated studies

From: The acute management of trauma hemorrhage: a systematic review of randomized controlled trials

Study Clinical group of trauma patients Intervention details Comparator details Primary endpoint Completion/Termination date
Warming techniques for treatment of hypothermia in polytrauma Adults, polytrauma, GCS > 9, ISS > 16 and ASCOT score = 2 to 50% Endovascular catheter + forced air warming Forced air warming Morbidity during length of stay Suspended July 2010. Insufficient numbers of patients recruited
Hypertonic fluids for resuscitation of hypovolemic shock Adults, prehospital SBP ≤ 70, or prehospital SBP 71-90 and HR ≥108 Arm A: 7.5% hypertonic saline/6% Dextran-70 Arm B: 7.5% hypertonic saline
three arm trial
Arm C: 0.9% normal saline 28-day survival Terminated August 2009 - no difference in 28-day survival (futility). Analysis reported earlier but not higher mortality with hypertonic saline arms.
Low dose vasopressin versus placebo in Traumatic Shock Resuscitation Adults, SBP < 90 mmHg Bolus vasopressin 4 U, then continuous infusion 2.4 U/hour for five hours Normal saline To develop new resuscitation regimens Terminated April 2009 - poor accrual rate
  1. ASCOT, a severity characterization of trauma score; rFVIIa, recombinant activated factor VII; SBP, systolic blood pressure.