Table 2 Terminated studies
From: The acute management of trauma hemorrhage: a systematic review of randomized controlled trials
Study | Clinical group of trauma patients | Intervention details | Comparator details | Primary endpoint | Completion/Termination date |
|---|---|---|---|---|---|
Warming techniques for treatment of hypothermia in polytrauma | Adults, polytrauma, GCS > 9, ISS > 16 and ASCOT score = 2 to 50% | Endovascular catheter + forced air warming | Forced air warming | Morbidity during length of stay | Suspended July 2010. Insufficient numbers of patients recruited |
Hypertonic fluids for resuscitation of hypovolemic shock | Adults, prehospital SBP ≤ 70, or prehospital SBP 71-90 and HR ≥108 | Arm A: 7.5% hypertonic saline/6% Dextran-70 Arm B: 7.5% hypertonic saline three arm trial | Arm C: 0.9% normal saline | 28-day survival | Terminated August 2009 - no difference in 28-day survival (futility). Analysis reported earlier but not higher mortality with hypertonic saline arms. |
Low dose vasopressin versus placebo in Traumatic Shock Resuscitation | Adults, SBP < 90 mmHg | Bolus vasopressin 4 U, then continuous infusion 2.4 U/hour for five hours | Normal saline | To develop new resuscitation regimens | Terminated April 2009 - poor accrual rate |