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Table 1 On-going studies

From: The acute management of trauma hemorrhage: a systematic review of randomized controlled trials

On-going study Clinical group of trauma patients Intervention details Comparator details Primary endpoint Target number to be recruited Expected end date
CRISTAL: Colloids versus crystalloids for resuscitation of critically ill patients ITU patients, fluid resuscitation Colloids Crystalloids 28 day mortality 3,010 March 2011
High versus low MAP for trauma patients undergoing surgery Adults, SBP < 90 mmHg, requiring laparotomy or thoracotomy, Target minimum mean arterial BP 50 mmHg Target minimum mean arterial BP 65 mmHg 30 day survival 271 July 2011
FIRST: Colloids versus crystalloids for resuscitation of trauma patients Adults, requiring ≥3 litres of fluid HES 130/0.4 in saline (Voluven) 0.9% saline Fluid volumes over first 24 hours 140 December 2009
Formula-driven vs. laboratory-guided transfusion in bleeding trauma patients: a feasibility study Adults, requiring four units of RBC in two hours and ongoing blood loss FFP:RBC:platelets ratio of 1:1:1 - formula Standard of care Protocol compliance at 12 hours 70 October 2011
  1. FFP, fresh frozen plasma; GCS, Glasgow coma score; ITU, intensive care unit; MAP, mean arterial pressure; RBC, red blood cell; SBP, systolic blood pressure.