Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study

Table 4 Predictors of liver impairment and ALT > 165 IU/l occurring on or after first day of statin administration

Variable	Univariable analyses			Multivariable analyses
	Odds ratio	95% CI	P value	Odds ratio	95% CI	P value
Liver impairment (n = 1,319)^a
Statin versus no statin	1.41	0.89 to 2.24	0.14	1.08	0.66 to 1.77	0.75
Age^b	1.005	0.99 to 1.02	0.36	0.99	0.98 to 1.004	0.21
Admission APACHE II score^b	1.06	1.03 to 1.09	< 0.0001	1.05	1.02 to 1.08	0.0007
APACHE II admission category (reference level: respiratory)			0.017			0.062
Cardiovascular	1.57	1.04 to 2.39	0.033	1.43	0.93 to 2.19	0.099
Gastrointestinal	1.46	0.76 to 2.80	0.25	1.67	0.86 to 3.25	0.13
Neurological	0.58	0.28 to 1.19	0.14	0.62	0.30 to 1.30	0.21
Gender (female)	0.62	0.41 to 0.94	0.028	0.65	0.42 to 0.99	0.043
Baseline hepatic SOFA			0.065			0.011
1 versus 0	0.58	0.36 to 0.92	0.02	0.49	0.30 to 0.79	0.0032
2 versus 0	0.85	0.49 to 1.46	0.56	0.67	0.38 to 1.18	0.17
Total baseline nonhepatic SOFA^b	1.36	1.19 to 1.55	< 0.0001	1.29	1.11 to 1.50	0.0009
ALT (n = 1,229)^c
Statin versus no statin	2.22	1.37 to 3.60	0.001	2.25	1.32 to 3.84	0.003
Age^b	1.00	0.98 to 1.01	0.46	0.99	0.97 to 1.002	0.091
Admission APACHE II score^b	1.05	1.01 to 1.08	0.005	1.04	1.01 to 1.08	0.016
APACHE II admission category (reference level: respiratory)			0.054			0.12
Cardiovascular	1.47	0.89 to 2.41	0.13	1.16	0.70 to 1.94	0.57
Gastrointestinal	0.30	0.072 to 1.25	0.098	0.40	0.094 to 1.70	0.21
Neurological	1.63	0.90 to 2.94	0.11	1.80	0.97 to 3.34	0.063
Gender (female)	0.77	0.48 to 1.22	0.26	0.90	0.56 to 1.45	0.67
Baseline ALT^d	1.14	1.08 to 1.20	< 0.0001	1.11	1.05 to 1.18	0.0001
Total baseline SOFA^b	1.10	0.96 to 1.26	0.17	1.08	0.94 to 1.25	0.26

Predictors of liver impairment and alanine transferase (ALT) > 165 IU/l occurring on or after the first day of statin administration. APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; SOFA, Sequential Organ Failure Assessment. ^aSeventy-eight patients were excluded from the model: 61 patients with missing data on at least one of the variables included in the model, and 17 patients with the APACHE II admission category of metabolic, of whom only one was in the statin group. ^bOdds ratios per one-unit increase. ^cA total of 168 patients were excluded from the model: 77 patients with baseline ALT > 165 IU/l, 75 with missing data for at least one of the variables included in the model, and 16 patients with the APACHE II admission category of metabolic, of whom only one was in the statin group. ^dOdds ratio per 10-unit increase.

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