A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis

Karvellas, Constantine J; Farhat, Maha R; Sajjad, Imran; Mogensen, Simon S; Leung, Alexander A; Wald, Ron; Bagshaw, Sean M

doi:10.1186/cc10061

Critical Care

Table 3 Characteristics of studies included in meta-analysis

From: A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis

Author:	Year	Study design	Population	Modality	Early (n)	Late (n)	Early criteria	Late criteria
Bouman [10]	2002	Randomised	Cardiac surgery/medical	CVVH	35	36	RRT within 12 hours if Urine Output <30 ml/hr	Urea >40 mmol/l or K >6.5 mmol/L
Sugahara [32]	2004	Randomised	Cardiac Surgery	CVVH	14	14	Urine Output <20 ml/hr	Urine Output <30 cc/hr
Liu [21]	2006	Prospective Cohort	Medical,Surgery	CRRT/IHD	122	121	Urea <27.1 mmol/L	Urea >27.1 mmol/L
Sabater [33]	2008	Prospective Cohort	Medical (Septic Shock)	CVVHF	9	23	Rifle Criteria (Risk, Injury)*	Rifle Criteria (Failure)**
Bagshaw [34]	2009	Prospective Cohort	Medical, Surgical	CRRT/IHD	618	619	Urea <24.2 mmol/L	Urea >24.2 mmol/L
Bagshaw [35]	2010	Prospective Cohort	Medical, Surgical	CRRT/IHD	117	117	Urea <23 mmol/L	Urea >23 mmol/L
Gettings [15]	1999	Retrospective Cohort	Trauma	CAVHD and CVVHD	41	59	Urea <21.4 mmol/L	Urea >21.4 mmol/L
Elahi [38]	2004	Retrospective Cohort	Cardiac surgery	CVVH	28	36	Urine Output <100 cc in 8 hrs	K >6 mmol/L, Cr >250 mmol/L
Dermirkilic [13]	2004	Retrospective Cohort	Cardiac Surgery	CVVHDF	27	34	Cr >400 μmol/L, Potassium >5.5 mmol/L	Oliguria
Andrade [36]	2007	Retrospective Cohort	Medical (ARDS/Sepsis)	IHD/SLED	18	15	On admission	At 24 hours
Wu [42]	2007	Retrospective Cohort	Surgical ALF	IHD/CVVH	54	26	Urea < 28.6 mmol/L	Urea >28.6 mmol/L
Manche [40]	2008	Retrospective Cohort	Cardiac Surgery	IHD	56	15	Hyperkalemia	U/O <0.5 ml/kg/hour
Iyem [39]	2009	Retrospective Cohort	Cardia Surgery	CVVH	95	90	RRT on admission	After 48 hours when anuric
Shiao [41]	2009	Retrospective Cohort	Surgery/Trauma	CVVH	51	47	Rifle Criteria (Risk)*	Rifle Injury, Failure**
Carl [37]	2010	Retrospective Cohort	Medical (sepsis)	CRRT/IHD	85	62	Urea <35.7 mmol/l	Urea >35.7 mmol/L

Abbreviations: Cr = creatinine (μmol/L); K = potassium (mmol/L).
RIFLE Criteria Risk: Increase in serum Creatinine by 1.5 times or urine output <0.5 ml/kg/hour × 6 hours.
RIFLE Criteria Injury: Increase in serum Creatinine by 2 times or urine output <0.5 ml/kg/hour × 12.
RIFLE Criteria Failure: Increase in serum Creatinine by 3 times or urine output <0.3 ml/kg/hour × 24.

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com