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  1. It has been 50 years since the pulmonary artery catheter was introduced, but the actual use of pulmonary artery catheters in recent years is unknown. Some randomized controlled trials have reported no causalit...

    Authors: Kentaro Fukano, Yusuke Iizuka, Seiya Nishiyama, Koichi Yoshinaga, Shigehiko Uchino, Yusuke Sasabuchi and Masamitsu Sanui
    Citation: Critical Care 2023 27:412
    Content type: Research Published on:

  2. Authors: Jheng‑Yan Wu, Ya‑Wen Tsai, Wan‑Hsuan Hsu, Ting‑Hui Liu, Po‑Yu Huang, Min‑Hsiang Chuang, Mei‑Yuan Liu and Chih‑Cheng Lai
    Citation: Critical Care 2023 27:411
    Content type: Correction Published on:

    The original article was published in Critical Care 2023 27:274

  3. To assess the association with outcomes of cardiac index (CI) and mixed venous oxygen saturation (SvO2) in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA).

    Authors: Johannes Grand, Christian Hassager, Henrik Schmidt, Simon Mølstrøm, Benjamin Nyholm, Henrik Frederiksen Høigaard, Jordi S. Dahl, Martin Meyer, Rasmus P. Beske, Laust Obling, Jesper Kjaergaard and Jacob E. Møller
    Citation: Critical Care 2023 27:410
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:492

    The Matters Arising to this article has been published in Critical Care 2023 27:451

  5. Dual circulation is a common but underrecognized physiological occurrence associated with peripheral venoarterial extracorporeal membrane oxygenation (ECMO). Competitive flow will develop between blood ejected...

    Authors: Richa Asija, Justin A. Fried, Eric C. Siddall, Dana A. Mullin, Cara L. Agerstrand, Daniel Brodie, Joshua R. Sonett, Philippe H. Lemaitre and Darryl Abrams
    Citation: Critical Care 2023 27:408
    Content type: Perspective Published on:

  6. This study aimed to quantitatively analyse ultra-early brain diffusion-weighted magnetic resonance imaging (DW-MRI) findings to determine the apparent diffusion coefficient (ADC) threshold associated with neur...

    Authors: Jung A. Yoon, Changshin Kang, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Nam In, Wonjoon Jeong, Hong Joon Ahn, In Ho Lee, Hye Seon Jeong, Byung Kook Lee and Jae Kwang Lee
    Citation: Critical Care 2023 27:407
    Content type: Research Published on:

  7. Venous thromboembolism (VTE) is a severe complication in critically ill patients, often resulting in death and long-term disability and is one of the major contributors to the global burden of disease. This st...

    Authors: Chengfu Guan, Fuxin Ma, Sijie Chang and Jinhua Zhang
    Citation: Critical Care 2023 27:406
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:495

  10. Shared decision-making is a joint process where patients, or their surrogates, and clinicians make health choices based on evidence and preferences. We aimed to determine the extent and predictors of shared de...

    Authors: Victoria Fleming, Abhinav Prasad, Connie Ge, Sybil Crawford, Shazeb Meraj, Catherine L. Hough, Bernard Lo, Shannon S. Carson, Jay Steingrub, Douglas B. White and Susanne Muehlschlegel
    Citation: Critical Care 2023 27:403
    Content type: Research Published on:

  12. Supplemental oxygen is commonly administered to patients after out-of-hospital cardiac arrest. However, the findings from studies on oxygen targeting for out-of-hospital cardiac arrest are inconclusive. Thus, ...

    Authors: Xin Cheng, Yu Zhang, Haidong Deng, Yuning Feng, Weelic Chong, Yang Hai, Pengfei Hao, Jialing He, Tiangui Li, Liyuan Peng, Peng Wang, Yangchun Xiao and Fang Fang
    Citation: Critical Care 2023 27:401
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:471

  13. Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop sepsis with very high endoto...

    Authors: John A. Kellum and Claudio Ronco
    Citation: Critical Care 2023 27:400
    Content type: Perspective Published on:

  14. Based on low-quality evidence, current nutrition guidelines recommend the delivery of high-dose protein in critically ill patients. The EFFORT Protein trial showed that higher protein dose is not associated wi...

    Authors: Christian Stoppe, Jayshil J. Patel, Alex Zarbock, Zheng-Yii Lee, Todd W. Rice, Bruno Mafrici, Rebecca Wehner, Man Hung Manuel Chan, Peter Chi Keung Lai, Kristen MacEachern, Pavlos Myrianthefs, Evdoxia Tsigou, Luis Ortiz-Reyes, Xuran Jiang, Andrew G. Day, M. Shahnaz Hasan…
    Citation: Critical Care 2023 27:399
    Content type: Research Published on:

  15. Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV), physiological data on l...

    Authors: Roberto Tonelli, Salvatore Grasso, Andrea Cortegiani, Lorenzo Ball, Ivana Castaniere, Luca Tabbì, Riccardo Fantini, Dario Andrisani, Filippo Gozzi, Antonio Moretti, Giulia Bruzzi, Linda Manicardi, Stefania Cerri, Anna Valeria Samarelli, Giulia Raineri, Francesco Murgolo…
    Citation: Critical Care 2023 27:398
    Content type: Brief Report Published on:

  19. Appropriate antibiotic (AB) therapy remains a challenge in the intensive care unit (ICU). Procalcitonin (PCT)-guided AB stewardship could help optimize AB treatment and decrease AB-related adverse effects, but...

    Authors: Márton Papp, Nikolett Kiss, Máté Baka, Domonkos Trásy, László Zubek, Péter Fehérvári, Andrea Harnos, Caner Turan, Péter Hegyi and Zsolt Molnár
    Citation: Critical Care 2023 27:394
    Content type: Research Published on:

  21. Mega-dose sodium ascorbate (NaAscorbate) appears beneficial in experimental sepsis. However, its physiological effects in patients with septic shock are unknown.

    Authors: Fumitaka Yanase, Sofia Spano, Akinori Maeda, Anis Chaba, Thummaporn Naorungroj, Connie Pei Chen Ow, Yugeesh R. Lankadeva, Clive N. May, Ashenafi H. Betrie, Darius J. R. Lane, Glenn M. Eastwood, Mark P. Plummer and Rinaldo Bellomo
    Citation: Critical Care 2023 27:371
    Content type: Research Published on:

  24. Various approaches have been suggested to identify acute kidney injury (AKI) early and to initiate kidney-protective measures in patients at risk or with AKI. The objective of this study was to evaluate whethe...

    Authors: Chun Yin See, Heng-Chih Pan, Jui-Yi Chen, Chun-Yi Wu, Hung-Wei Liao, Yen-Ta Huang, Jung-Hua Liu, Vin-Cent Wu and Marlies Ostermann
    Citation: Critical Care 2023 27:390
    Content type: Research Published on:

  25. Low levels of high-density lipoprotein (HDL) cholesterol have been associated with higher rates and severity of infection. Alterations in inflammatory mediators and infection are associated with alterations in...

    Authors: Fergus Hamilton, Kasper Mønsted Pedersen, Peter Ghazal, Børge Grønne Nordestgaard and George Davey Smith
    Citation: Critical Care 2023 27:389
    Content type: Research Published on:

  26. Though early hypotension after pediatric in-hospital cardiac arrest (IHCA) is associated with inferior outcomes, ideal post-arrest blood pressure (BP) targets have not been established. We aimed to leverage pr...

    Authors: Monique M. Gardner, David A. Hehir, Ron W. Reeder, Tageldin Ahmed, Michael J. Bell, Robert A. Berg, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. Carcillo, Todd C. Carpenter, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. Fink…
    Citation: Critical Care 2023 27:388
    Content type: Research Published on:

  27. Neurological damage is the main cause of death or withdrawal of care in comatose survivors of cardiac arrest (CA). Hypoxemia and hyperoxemia following CA were described as potentially harmful, but reports were...

    Authors: S. Macherey-Meyer, S. Heyne, M. M. Meertens, S. Braumann, C. Hueser, V. Mauri, S. Baldus, S. Lee and C. Adler
    Citation: Critical Care 2023 27:387
    Content type: Research Published on:

  28. Sepsis-associated encephalopathy is a severe neurologic syndrome characterized by a diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of diagnostic tools and management...

    Authors: Romain Sonneville, Sarah Benghanem, Lina Jeantin, Etienne de Montmollin, Marc Doman, Augustin Gaudemer, Michael Thy and Jean-François Timsit
    Citation: Critical Care 2023 27:386
    Content type: Review Published on:

  29. Patients undergoing mechanical ventilation (MV) for COVID-19 exhibit an increased risk of ventilator-associated pneumonia (VAP). The occurrence of lung abscesses following VAP in these patients has been poorly...

    Authors: S. Hraiech, K. Ladjal, C. Guervilly, H. Hyvernat, L. Papazian, J. M. Forel, A. Lopez, N. Peres, J. Dellamonica, M. Leone and I. Gragueb-Chatti
    Citation: Critical Care 2023 27:385
    Content type: Research Published on:

  32. Regardless of the available antifungals, intraabdominal candidiasis (IAC) mortality continues to be high and represents a challenge for clinicians.

    Authors: Emilio Maseda, Ignacio Martín-Loeches, Rafael Zaragoza, Javier Pemán, Jesús Fortún, Santiago Grau, Gerardo Aguilar, Marina Varela, Marcio Borges, María-José Giménez and Alejandro Rodríguez
    Citation: Critical Care 2023 27:382
    Content type: Perspective Published on:

  33. Restoring plasma arginine levels through enteral administration of L-citrulline in critically ill patients may improve outcomes. We aimed to evaluate whether enteral L-citrulline administration reduced organ d...

    Authors: Jean-Marc Tadié, Clara Locher, Adel Maamar, Jean Reignier, Pierre Asfar, Morgane Commereuc, Mathieu Lesouhaitier, Murielle Gregoire, Estelle Le Pabic, Claude Bendavid, Caroline Moreau, Jean-Luc Diehl, Alain Gey, Eric Tartour, Yves Le Tulzo, Ronan Thibault…
    Citation: Critical Care 2023 27:381
    Content type: Research Published on:

  35. Out-of-plane (OOP) approach is frequently used for ultrasound-guided insertion of central venous catheter (CVC) owing to its simplicity but does not avoid mechanical complication. In-plane (IP) approach might ...

    Authors: Antoine Villa, Vladimir Hermand, Vincent Bonny, Gabriel Preda, Tomas Urbina, Maxime Gasperment, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Daniel Zafimahazo, Jérémie Joffre, Hafid Ait-Oufella and Eric Maury
    Citation: Critical Care 2023 27:379
    Content type: Brief Report Published on:

  36. Reintubation is a common complication in critically ill patients requiring mechanical ventilation. Although reintubation has been demonstrated to be associated with patient outcomes, its time definition varies...

    Authors: Aiko Tanaka, Yoshimitsu Shimomura, Akinori Uchiyama, Natsuko Tokuhira, Tetsuhisa Kitamura, Hirofumi Iwata, Haruka Hashimoto, Suguru Ishigaki, Yusuke Enokidani, Tomonori Yamashita, Yukiko Koyama, Naoya Iguchi, Takeshi Yoshida and Yuji Fujino
    Citation: Critical Care 2023 27:378
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2024 28:37

    The Matters Arising to this article has been published in Critical Care 2023 27:395

  38. Cancer and sepsis share risk factors, and sepsis patients may have impaired immune response and increased morbidity long after intensive care. This study aimed to assess whether sepsis survivors are at increas...

    Authors: Johanna Hästbacka, Anna But, Gunnar Strandberg and Miklós Lipcsey
    Citation: Critical Care 2023 27:376
    Content type: Research Published on:

  40. The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activate...

    Authors: Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, Michelle Chew and Alexandru Schiopu
    Citation: Critical Care 2023 27:374
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2024 28:9

    The Matters Arising to this article has been published in Critical Care 2023 27:480

  41. Response to prophylactic platelet transfusion is suspected to be inconsistent in critically ill patients questioning how to optimize transfusion practices. This study aimed to describe prophylactic platelet tr...

    Authors: Florian Reizine, Sarah Le Marec, Anthony Le Meur, Maëlys Consigny, Florian Berteau, Laetitia Bodenes, Marie Geslain, Zoe McQuilten, Catherine Le Niger, Julien Huntzinger, Philippe Seguin, Jean-Baptiste Thibert, David Simon, Jean Reignier, Pierre-Yves Egreteau, Jean-Marc Tadié…
    Citation: Critical Care 2023 27:373
    Content type: Research Published on:

  42. Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying mechanisms is needed to develop targeted therapie...

    Authors: Julia Leonhardt, Mirrin J. Dorresteijn, Sophie Neugebauer, Diana Mihaylov, Julia Kunze, Ignacio Rubio, Frank-Stephan Hohberger, Silke Leonhardt, Michael Kiehntopf, Klaus Stahl, Christian Bode, Sascha David, Frank A. D. T. G. Wagener, Peter Pickkers and Michael Bauer
    Citation: Critical Care 2023 27:372
    Content type: Research Published on:

  43. The primary aim was to explore the concept of isolated and combined threshold-insults for brain tissue oxygenation (pbtO2) in relation to outcome in traumatic brain injury (TBI).

    Authors: Teodor Svedung Wettervik, Erta Beqiri, Anders Hånell, Stefan Yu Bögli, Michal Placek, Mathew R. Guilfoyle, Adel Helmy, Andrea Lavinio, Ronan O’Leary, Peter J. Hutchinson and Peter Smielewski
    Citation: Critical Care 2023 27:370
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:396

  44. No univocal recommendation exists for microbiological diagnosis of ventilator-associated pneumonia (VAP). Sampling of either proximal or distal respiratory tract likely impacts on the broad range of VAP incide...

    Authors: Davide Mangioni, Mauro Panigada, Emanuele Palomba, Chiara Bobbio, Liliane Chatenoud, Laura Alagna, Jacopo Fumagalli, Andrea Gori, Anna Grancini, Amedeo Guzzardella, Andrea Lombardi, Caterina Matinato, Andrea Meli, Antonio Muscatello, Laura Porretti, Mara Tomasello…
    Citation: Critical Care 2023 27:369
    Content type: Research Published on:

  45. Extubation failure is associated with increased mortality. Cough ineffectiveness may be associated with extubation failure, but its quantification for patients undergoing weaning from invasive mechanical venti...

    Authors: Vincent Bonny, Jeremie Joffre, Paul Gabarre, Tomas Urbina, Louai Missri, Mathilde Ladoire, Maxime Gasperment, Jean-Luc Baudel, Bertrand Guidet, Guillaume Dumas, Eric Maury, Laurent Brochard and Hafid Ait-Oufella
    Citation: Critical Care 2023 27:368
    Content type: Brief Report Published on:

  47. Critical care patients often require central venous cannulation (CVC). We hypothesized that real-time biplane ultrasound-guided CVC would improve first-puncture success rate and reduce mechanical complications...

    Authors: Ying-Ying Li, Yi-Hao Liu, Lin Yan, Jing Xiao, Xin-Yang Li, Jun Ma, Li-Gang Jia, Rui Chen, Chao Zhang, Zhen Yang, Ming-Bo Zhang and Yu-Kun Luo
    Citation: Critical Care 2023 27:366
    Content type: Research Published on:

  50. While numerous randomized controlled trials (RCTs) have been conducted in the field of trauma, a substantial portion of them are yielding negative results. One potential contributing factor to this trend could...

    Authors: Thomas Jeanmougin, Elaine Cole, Baptiste Duceau, Mathieu Raux and Arthur James
    Citation: Critical Care 2023 27:363
    Content type: Research Published on:
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Critical Care

ISSN: 1364-8535