Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

Table 2 Major inflammatory factors that modulate HIF-1α

Inflammatory factors	Model	Molecular mechanism/signaling pathway	Regulation of HIF-1α	References
IL-1β	In vitro	NF-κΒ/COX-2	Up	[90]
IL-2	In vitro	PI3K/AKT	Up	[91]
IL-4	In vitro	PI3K/AKT	Up	[92]
IL-6	In vitro	STAT3	Up	[93]
IL-8	Mouse fatty liver model	PI3K/AKT	Up	[94]
IL-10	Rat hypoxia model	Not given	None	[95]
IL-13	In vitro	Induce hypoxia signaling pathway genes	Up	[96]
IL-15	In vitro	STAT3	Up	[97]
IL-17	MTB Mouse model	Not given	Down	[98]
IL-18	Bioinformatics analysis	NF-κB	Up	[99]
IL-27	In vitro	STAT1	Down	[100]
IL-33	Murine model of HPH	IL-33/ST2/HIF-1α	Up	[101]
IL-34	Clinical research	Not given	Up	[102]
IL-37	PDAC	Inhibition of STAT3	Down	[103]
IL-38	CIA rats	SIRT1/HIF-1α	Down	[104]
TNF-α	In vitro	IKKβ	Up	[105]
IFN	In vitro	PI3K/AKT	Up	[106]
NO	In vitro	PI3K/AKT	Up	[107]
ROS	In vitro	Inactivate PHD	Up	[108]

CIA collagen-induced arthritis, HPH hypoxia-induced pulmonary hypertension, IKKβ I kappa B kinase beta, MTB Mycobacterium tuberculosis, PDAC pancreatic ductal adenocarcinoma, Ref reference, ROS Reactive Oxygen Species

ISSN: 1364-8535