Fig. 5From: Vascular leak in sepsis: physiological basis and potential therapeutic advancesNormal oxygen diffusion from blood vessels to target tissue cells. b Tissue hypoxia occurring due to increased diffusion distance between oxygen carrying red blood cells in the microvascular blood vessels and the mitochondria of tissue cells. c Tissue hypoxia occurring due to a tamponade like effect of interstitial fluid on microvascular blood vesselsBack to article page