Fig. 4From: Vascular leak in sepsis: physiological basis and potential therapeutic advancesIn sepsis Ang-2 acts as an antagonist of Tie 2 which results in disruption of protective Ang-1/Tie 2 signalling. The antagonistic effects of Ang-2 leads to increased inflammation and inhibition of the vascular stabilising Akt signalling pathway. Moreover, the vascular barrier protective effects of Tie 2 are abrogated by the cleaving properties of MMP14Back to article page