Fig. 1From: Vascular leak in sepsis: physiological basis and potential therapeutic advancesEndothelial cell–cell junction complexes. These key junctional structures maintain endothelial barrier integrity. The ZO proteins link the membrane proteins to the filamentous cytoskeleton. Members of the Rho family of GTPases mediate opposing changes in endothelial cell permeability with Rac1 stabilising the VE-cadherin complex and RhoA de-stabilising the VE-cadherin complexBack to article page