Table 1 Characteristics of included patients
Parameters | Total (n = 50) | Saline (n = 21) | Albumin (n = 29) | P value |
|---|---|---|---|---|
General characteristics | ||||
Age, years | 68 [60–76] | 68 [62–74] | 70 [78–85] | 0.83 |
BMI, kg/m2 | 23.5 [21.4–28.3] | 25.2 [22.8–29.1] | 22.9 [18.9–26.9] | 0.06 |
Female | 13 (26) | 3 (14) | 10 (34) | 0.11 |
Comorbidities | ||||
Vascular disease | 16 (32) | 9 (43) | 7 (24) | 0.22 |
Hypertension | 21 (42) | 10 (48) | 11(38) | 0.57 |
Diabetes | 10 (20) | 4 (19) | 6 (21) | > 0.99 |
Chronic kidney disease | 4 (16) | 2 (10) | 5 (17) | 0.68 |
Cancer | 27 (54) | 13 (62) | 14 (48) | 0.40 |
Primary site of infection | ||||
Lung | 27 (54) | 14 (67) | 13 (45) | 0.16 |
Abdomen | 12 (24) | 5 (24) | 7 (24) | > 0.99 |
Urinary | 9 (18) | 2 (9) | 7 (28) | 0.27 |
Soft tissue | 2 (4) | 0 (0) | 2 (7) | 0.22 |
Time before inclusion, hour | 12 [6–15] | 12 [6–20] | 8 [6–14] | 0.10 |
Fluid resuscitation before inclusion, L | 2 [1.5–2.5] | 1.5 [1.4–2.5] | 2 [1.5–2.5] | 0.53 |
Severity score | ||||
SAPS II | 53 [45–70] | 52 [45–66] | 55 [43–73] | 0.75 |
SOFA | 8 [5–11] | 8 [6–11] | 8 [5–11] | 0.75 |
Organ support therapy | ||||
Norepinephrine | ||||
N | 33 (66) | 13 (62) | 20 (69) | 0.59 |
Dose, µg/kg/min | 0.5 [0.3–0.9] | 0.4 [0.3–0.5] | 0.7 [0.3–1.0] | 0.06 |
Invasive mechanical ventilation | 28 (56) | 13 (62) | 15 (52) | 0.57 |
Global hemodynamics | ||||
Heart rate, bpm | 98 [77–115] | 91 [77–115] | 101 [85–115] | 0.60 |
Mean arterial pressure, mmHg | 72 [67–81] | 75 [67–78] | 72 [69–81] | 0.93 |
Echocardiography | ||||
Cardiac index, L/min/m2 | 2.3 [2–2.9] | 2.4 [2.2–2.9] | 2.3 [1.9–2.8] | 0.56 |
LVEF, % | 50 [45–60] | 50 [49–55] | 50 [45–60] | 0.54 |
Tissue perfusion | ||||
Knee CRT | 4.4 [3.5–5.3] | 4.3 [3.6–5] | 4.6 [3.5–5.3] | 0.78 |
Index CRT | 3.5 [3.2–3.9] | 3.5 [3.2–3.9] | 3.6 [3.4–4.0] | 0.47 |
Mottling score | 1 [1, 2] | 2 [1–3] | 1 [1, 2] | 0.34 |
Biology | ||||
Arterial lactate, mmol/l | 2.2 [1.3–3.1] | 2.2 [1.3–3.1] | 2.4 [1.2–3.2] | 0.62 |
Creatininemia, µmol/l | 112 [76–230] | 117 [84–194] | 106 [68–269] | 0.94 |
Albuminemia, g/l | 22.4 [20–25.7] | 20.6 [16.6–22.2] | 23.6 [21.1–26] | 0.15 |