Fig. 1
Monitoring of immature neutrophils and LOX‐1 PMN‐MDSC over time in COVID-19 and septic shock patients. A Table depicting patients’ main characteristics. B Percentages of immature neutrophils (CD10lowCD16low) among total neutrophils were measured in peripheral blood from 15 healthy controls and 14 COVID‐19 ICU patients (D0: n = 14; D3: n = 12; and D7: n = 6), or 17 septic shock patients (D0: n = 15; D3: n = 14; and D7: n = 6). Percentages of LOX‐1 MDSCs among total neutrophils were measured in peripheral blood from 15 healthy controls and 15 COVID‐19 ICU patients (D0: n = 15; D3: n = 13; and D7: n = 7), or 17 septic shock patients (D0: n = 14; D3: n = 13; and D7: n = 7). Nonparametric Mann–Whitney U-test was used to compare values between controls and patients (** p < 0.01 and *** p < 0.001). C Correlation of LOX‐1 MDSCs and immature neutrophils in COVID-19 patients (left panel) and septic shock patients (right panel). Correlations were calculated using Spearman correlation test. D Representative examples (D0 and D7) of LOX‐1 MDSCs (CD45lowLOX-1pos, supper panel) and immature neutrophils (CD10lowCD16low, lower panel) characterization for one COVID‐19 ICU patient (left panels) and one septic shock patient (right panels). Cells were gated on whole neutrophil population based on CD45/SSC characteristics. LOX-1 MDSCs from COVID-19 patients are coloured in orange. LOX-1 MDSCs from septic shock patients are coloured in blue