Table 1 Characteristics of ICUs and patients before and after propensity score matching
From: Low-dose immunoglobulin G is not associated with mortality in patients with sepsis and septic shock
| Â | Before propensity score matching | After propensity score matching | ||||
|---|---|---|---|---|---|---|
IVIgG(+) | IVIgG(–) | SD (%) | IVIgG(+) | IVIgG(–) | SD (%) | |
n (%) | 960 (30.8) | 2158 (69.2) | Â | 653 | 653 | Â |
ICU characteristics | ||||||
ICU beds volume | 12 (10–19) | 12 (8–19) | 13.3 | 10 (8–16) | 12 (8–18) | 9.8 |
ICU type | ||||||
 ER ICU | 464 (48.3) | 1077 (49.9) | 3.2 | 308 (47.2) | 308 (47.2) | 0.0 |
 General ICU | 496 (51.7) | 1081 (50.1) | 3.2 | 345 (52.8) | 345 (52.8) | 0.0 |
Intensity of intensivists | ||||||
 Closed ICU model | 453 (47.2) | 1102 (51.1) | 7.8 | 329 (50.4) | 326 (49.9) | 1.0 |
 Open ICU model | 326 (34.0) | 752 (34.8) | 1.7 | 198 (30.3) | 208 (31.9) | 3.4 |
 Intensivist co-management model | 181 (18.9) | 304 (14.1) | 12.9 | 126 (19.3) | 119 (18.2) | 2.8 |
Preference to DIC therapy (%) | ||||||
 Actively (radical) | 763 (79.5) | 1031 (47.8) | 69.8 | 468 (71.7) | 461 (70.6) | 2.4 |
 Not actively (conservative) | 23 (4.4) | 505 (23.4) | 57.1 | 23 (3.5) | 24 (3.7) | 1.1 |
 Neither (treat DIC occasionally) | 174 (18.1) | 622 (28.8) | 25.5 | 162 (24.8) | 168 (25.7) | 2.1 |
Patient characteristics | ||||||
Age (years) | 70 (61–79) | 73 (63–81) | 16.5 | 72 (62–80) | 72 (62–80) | 1.6 |
Gender (male) (%) | 563 (58.6) | 1307 (60.6) | 4.1 | 395 (60.5) | 394 (60.3) | 0.4 |
Weight (kg) | 55.9 (47.2–65.0) | 54.0 (46.2–64.0) | 5.8 | 55.7 (47.0–65.0) | 54.0 (46.0–63.4) | 7.2 |
Prior location (%) | ||||||
 Outpatient (ER) | 354 (36.9) | 1049 (48.6) | 23.8 | 272 (41.7) | 287 (44.0) | 4.6 |
 In-hospital (general ward) | 329 (34.3) | 588 (27.2) | 15.4 | 189 (28.9) | 184 (28.2) | 4.6 |
 Transferred from other hospital | 277 (28.9) | 521 (24.1) | 10.9 | 192 (29.4) | 182 (27.9) | 3.3 |
SIRS score day1 | 3 (2–4) | 3 (2–4) | 4.4 | 3 (2–4) | 3 (2–4) | 1.1 |
APACHEII | 24 (17–30) | 22 (16–28) | 18.3 | 23 (17–30) | 23 (17–29) | 5.4 |
SOFA score day1 | ||||||
 Respiratory | 2 (1–3) | 2 (1–3) | 11.6 | 2 (1–3) | 2 (1–3) | 3.3 |
 Hematologic | 1 (0–2) | 1 (0–2) | 24.4 | 1 (0–2) | 1 (0–2) | 0.8 |
 Hepatic | 0 (0–1) | 0 (0–1) | 12.1 | 0 (0–1) | 0 (0–1) | 0.0 |
 Cardiovascular | 3 (2–4) | 3 (1–4) | 29.6 | 3 (1–4) | 3 (1–4) | 5.8 |
 Neurologic | 1 (0–3) | 1 (0–3) | 9.9 | 1 (0–3) | 1 (0–3) | 4.9 |
 Renal | 2 (0–3) | 1 (0–3) | 15.1 | 2 (0–3) | 2 (0–3) | 7.6 |
Laboratory data day1 | ||||||
 White blood cell count (109/l) | 10.6 (3.3–17.9) | 11.5 (5.5–17.7) | 1.8 | 11.8 (3.8–18.8) | 11.4 (5.1–17.7) | 2.3 |
 Hemoglobin (g/dl) | 10.5 (8.9–12.2) | 10.7 (9.0–12.6) | 6.7 | 10.6 (9.0–12.3) | 10.6 (9.1–12.6) | 0.8 |
 Platelet count (109/l) | 107 (54–172) | 130 (72–203) | 21.1 | 118 (64–188) | 125 (66–194) | 1.6 |
Comorbidity | ||||||
 Liver | 52 (5.4) | 75 (3.5) | 9.2 | 25 (3.8) | 34 (5.2) | 6.8 |
 Respiratory | 38 (4.0) | 82 (3.8) | 1.0 | 29 (4.4) | 29 (4.4) | 0.0 |
 Cardiovascular | 65 (6.8) | 113 (5.2) | 6.7 | 40 (6.1) | 45 (6.9) | 3.2 |
 Renal | 82 (8.5) | 173 (8.0) | 1.8 | 50 (7.7) | 57 (8.7) | 3.6 |
 Immunocompromised | 174 (18.1) | 310 (14.4) | 10.0 | 107 (16.4) | 99 (15.2) | 3.3 |
Pre-existing coagulopathy (%) | ||||||
 Cirrhosis/liver failure | 45 (4.7) | 75 (3.5) | 6.1 | 24 (3.7) | 28 (4.3) | 3.1 |
 Chemotherapy | 48 (5.0) | 94 (4.4) | 2.8 | 31 (4.7) | 35 (5.4) | 3.2 |
 Hematologic malignancy | 40 (4.2) | 58 (2.7) | 8.2 | 16 (2.5) | 24 (3.7) | 6.9 |
 Medication of warfarin | 31 (3.2) | 120 (5.6) | 11.7 | 29 (4.4) | 26 (4.0) | 2.0 |
 Others | 19 (2.0) | 36 (1.7) | 2.2 | 16 (2.5) | 14 (2.1) | 2.7 |
Infection site (%) | ||||||
 Abdomen | 346 (36.0) | 674 (31.2) | 10.2 | 234 (35.8) | 222 (34.0) | 3.8 |
 Lung | 226 (23.5) | 571 (26.5) | 6.9 | 159 (24.3) | 162 (24.8) | 1.2 |
 Urinary tract | 133 (13.9) | 361 (16.7) | 7.8 | 98 (15.0) | 102 (15.6) | 1.7 |
 Musculoskeletal | 128 (13.3) | 238 (11.0) | 7.0 | 75 (11.5) | 75 (11.5) | 0.0 |
 Infectious endocarditis | 21 (2.2) | 47 (2.0) | 1.4 | 14 (2.1) | 12 (1.2) | 7.1 |
 Others | 14 (1.5) | 44 (2.0) | 3.8 | 13 (2.0) | 16 (2.5) | 3.4 |
 Central nerve system | 19 (2.0) | 42 (1.9) | 0.7 | 14 (2.1) | 14 (2.1) | 0.0 |
 CRBSI | 21 (2.2) | 23 (1.1) | 8.6 | 7 (1.1) | 9 (1.4) | 2.6 |
 Unknown | 52 (5.4) | 162 (7.5) | 8.5 | 39 (6.0) | 41 (6.3) | 1.3 |
Blood culture (%) | ||||||
 Positive | 438 (45.6) | 931 (43.1) | 5.0 | 286 (43.8) | 282 (43.2) | 1.2 |
 Negative | 464 (48.3) | 1100 (51.0) | 5.4 | 324 (49.6) | 320 (49.0) | 1.2 |
 Not taken | 58 (6.0) | 127 (5.9) | 0.4 | 43 (6.6) | 51 (7.8) | 4.6 |
Microorganism (%) | ||||||
 Gram-negative rod | 379 (39.5) | 753 (34.9) | 9.5 | 254 (38.9) | 240 (36.8) | 4.3 |
 Gram-positive cocci | 268 (27.9) | 458 (21.2) | 15.6 | 150 (23.0) | 165 (25.3) | 5.4 |
 Combined | 110 (11.5) | 287 (13.3) | 5.5 | 86 (13.2) | 81 (12.4) | 2.4 |
 Others | 13 (1.4) | 45 (2.1) | 5.3 | 10 (1.5) | 9 (1.4) | 0.8 |
 Fungus | 13 (1.4) | 42 (1.9) | 3.9 | 11 (1.7) | 8 (1.2) | 4.2 |
 Virus | 5 (0.5) | 23 (1.1) | 6.7 | 5 (0.8) | 4 (0.6) | 2.4 |
 Unknown | 172 (17.9) | 550 (25.5) | 18.5 | 137 (21.0) | 146 (22.4) | 3.4 |
Surgical intervention/drainage (%) | 466 (48.5) | 848 (39.3) | 18.6 | 353 (54.1) | 351 (53.8) | 0.6 |