All patients | Conventional adaptation strategy | BLT-guided adaptation strategy | p | |
---|---|---|---|---|
(n = 122) | (n = 61) | (n = 61) | ||
Appropriate empirical antimicrobial therapy, % (n) | 80% (98) | 77% (47) | 84% (51) | 0.45 |
Early escalation, % (n) | 7% (9) | 0% (0) | 15% (9) | <0.01* |
Appropriate antimicrobial therapy after culture results, % (n) | 88% (107) | 77% (47) | 98% (60) | <0.01 |
Delay before antimicrobial therapy escalation (h) | 48 (28–60) | 50.5 (48–73) | 27 (24–28) | <0.01# |
Optimal empirical antimicrobial therapy, % (n) | 51% (62) | 46% (28) | 56% (34) | 0.33 |
Early adaptation, % (n) | 22% (27) | 2% (1) | 43% (26) | <0.01* |
escalation | 7% (9) | 0% (0) | 15% (9) | |
de-escalation | 15% (18) | 2% (1) | 28% (17) | |
Optimal antimicrobial therapy after culture results, % (n) | 71% (87) | 48% (29) | 95% (58) | <0.01 |
Delay before antimicrobial therapy adaptation (h) | 49 (31.5–65) | 58 (48–72) | 28 (24.5–47) | <0.01# |
Time to apyrexia (h) | 24 (24–72) | 24 (24–48) | 30 (24–72) | 0.19# |
Time to leukocytosis <10.000/mm3 (days) | 6 (3–13) | 5 (3–12) | 6 (3–15) | 0.37# |
Time to mechanical weaning (days) | 5 (3–9) | 4.5 (3–9) | 5 (4–8) | 0.51# |
Length of ICU stay (days) | 10 (5–16) | 11 (6–17) | 10 (5–15) | 0.48 |
Mortality, % (n) | 15% (18) | 16% (10) | 13% (8) | 0.80 |