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Fig. 4 | Critical Care

Fig. 4

From: Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome

Fig. 4

TNF-α production by LPS-stimulated PBMCs as an index of sepsis-induced immunosuppression. a Comparative production of TNF-α by PBMCs from healthy control subjects and patients after stimulation with LPS and Pam3Cys. The exact p values after correction for multiple testing are provided: a9.8 × 10−4; b2.5 × 10−3; c7.6 × 10−4; d5.7 × 10−4; enon-significant. b ROC curve analysis to identify a cut-off concentration of TNF-α produced by PBMCs after stimulation with LPS on day 3 between patients and healthy control subjects. c Survival analysis between patients with production of TNF-α less than 250 pg/ml (defective, n = 42) and patients with production of TNF-α more than 250 pg/ml (adequate, n = 46). p Values of significance are provided. LPS Lipopolysaccharide, PBMC Peripheral blood mononuclear cell, TNF-α Tumour necrosis factor-α

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Critical Care

ISSN: 1364-8535