| Day 28 | Day 60 | ||||||
---|---|---|---|---|---|---|---|---|
Subgroup | Hydrocortisone (n = 98) | Placebo (n = 99) | Relative risk with hydrocortisone (95 % CI) | p Value | Hydrocortisone (n = 98) | Placebo (n = 99) | Relative risk with hydrocortisone (95 % CI) | p Value |
Age | ||||||||
 Age ≤65 years, n/total (%) | 12/50 (24.0) | 16/50 (32.0) | 0.75 (0.40–1.42) | 0.50 | 18/50 (36.0) | 19/50 (38.0) | 0.95 (0.57–1.58) | 1.00 |
 Age >65 years, n/total (%) | 10/48 (20.8) | 11/49 (22.5) | 0.93 (0.43–1.98) | 1.00 | 16/48 (33.3) | 21/49 (42.9) | 0.78 (0.47–1.3) | 0.40 |
APACHE II score | ||||||||
 APACHE II score <25, n/total (%) | 8/61 (13.1) | 14/65 (21.5) | 0.61 (0.27–1.35) | 0.25 | 16/61 (26.2) | 22/65 (33.8) | 0.61 (0.27–1.35) | 0.44 |
 APACHE II score ≥ 25, n/total (%) | 14/37 (37.8) | 13/34 (38.2) | 0.99 (0.55–1.79) | 1.00 | 18/37 (48.7) | 18/34 (52.9) | 0.92 (0.58–1.45) | 0.81 |
Lung injury score | ||||||||
 Lung injury score < 2.5, n/total (%) | 11/54 (20.4) | 13/58 (22.4) | 0.91 (0.45–1.85) | 0.82 | 16/54 (29.6) | 17/58 (29.3) | 1.01 (0.60–1.79) | 1.00 |
 Lung injury score ≥ 2.5, n/total (%) | 11/44 (25) | 13/40 (32.5) | 0.77 (0.39–0.52) | 0.48 | 18/44 (40.9) | 22/40 (55.0) | 0.74 (0.47–1.17) | 0.27 |
Sepsis severity | ||||||||
 Severe sepsis without shock, n/total (%) | 3/20 (15.0) | 3/23 (13.0) | 1.15 (0.26–5.07) | 1.00 | 4/20 (20.0) | 5/23 (21.7) | 0.92 (0.29–2.97) | 1.00 |
 Vasopressor dependent shock, n/total (%) | 19/78 (24.4) | 24/76 (31.6) | 0.77 (0.46–1.29) | 0.37 | 30/78 (38.5) | 35/76 (46.1) | 0.84 (0.58–1.21) | 0.41 |
ARDS severity | ||||||||
 Mild ARDS, n/total (%) | 5/30 (16.7) | 7/32 (21.9) | 0.76 (0.27–2.14) | 0.75 | 9/30 (30.0) | 10/32 (31.3) | 0.96 (0.45–2.03) | 1.00 |
 Moderate to severe ARDS, n/total (%) | 17/68 (25.0) | 20/67 (29.9) | 0.84 (0.48–1.45) | 0.57 | 25/68 (36.8) | 30/67 (44.8) | 0.82 (0.55–1.24) | 0.38 |
Source of infection | ||||||||
 Pneumonia, n/total (%) | 11/49 (22.5) | 13/51 (25.5) | 0.88 (0.44–1.77) | 0.82 | 18/49 (36.7) | 19/51 (37.3) | 0.99 (0.59–1.64) | 1.00 |
 Others, n/total (%) | 1/10 (10.0) | 6/18 (33.3) | 0.30 (0.04–2.15) | 0.36 | 1/10 (10.0) | 7/18 (38.9) | 0.26 (0.04–1.80) | 0.19 |
Number of comorbidities | ||||||||
  ≤ 2 comorbidities, n/total (%) | 18/67 (26.9) | 22/77 (28.6) | 0.94 (0.55–1.60) | 0.85 | 25/67 (37.3) | 30/77 (39.0) | 0.96 (0.63–1.45) | 0.87 |
  ≥ 3 comorbidities, n/total (%) | 4/31 (12.9) | 5/22 (22.7) | 0.57 (0.17–1.88) | 0.46 | 9/31 (29.0) | 10/2 (45.5) | 0.64 (0.31–1.31) | 0.26 |