Table 3 Mixed models analysis of HLA-DR expression and LPS-induced TNF-ɑ production in septic patients who did and did not develop a secondary infection

HLA-DR expression (antibodies/cell), median (IQR)

Sample A (days 1–2)^a

6761 (4054, 12,326)

n = 53

11,133 (4054, 16,897)

n = 20

Sample B (days 3–4)^a

8085 (4171, 15,951)

n = 39

9438 (4008, 17,236)

n = 20

Sample C (days 6–8)^a

9662 (6488, 17,165)

n = 15

9722 (4852, 15,324)

n = 13

Δ Sample A to B

918 (-1242, 4132)

-934 (-6505, 353)

Δ Sample A to C

3621 (-410, 9284)

-1479 (-3382, 1662)

LPS-induced TNF-ɑ production (pg/ml), median (IQR)

Sample A (days 1–2)^a

171 (76, 400)

n = 53

266 (73, 523)

n = 19

Sample B (days 3–4)^a

227 (132, 341)

n = 39

206 (46, 574)

n = 17

Sample C (days 6–8)^a

282 (111, 427)

n = 17

268 (52, 368)

n = 10

Δ Sample A to B

-3 (-137, 55)

16 (-48, 65)

Δ Sample A to C

7 (-140, 97)

38 (-43, 120)