Table 2 Gut–lung crosstalk
From: The digestive tract as the origin of systemic inflammation
Major finding | Study type | Reference |
|---|---|---|
Cross-transfusion of mesenteric lymph from donors after shock/trauma induces acute lung injury in recipients | Rodent | [97] |
Post-shock mesenteric lymph contains increased amounts of bioactive lysophospholipids and PUFAs | Rodent | [101] |
Post-shock mesenteric lymph contains increased amounts of free fatty acids | Rodent | [102] |
The detrimental effects of post-shock mesenteric lymph can be reversed by the addition of albumin | Rodent | [103] |
Inhibition of PLA2 inhibits the cytotoxic activity of post-shock mesenteric lymph | Rodent | [105] |
Levels of Paneth cell-derived α-defensin 4 (an antimicrobial peptide) are increased in post-shock mesenteric lymph | Rodent | [107] |
Endogenous alarmins are abundantly released from the intestines in post-shock mesenteric lymph | Rodent | [113] |