Table 3 Incidence and clinical characteristics of diastolic dysfunction by definition employed
From: Application of a simplified definition of diastolic function in severe sepsis and septic shock
Characteristic | Grade 0 | Grade I | Grade II | Grade III | p Value |
|---|---|---|---|---|---|
ASE definition (n = 58 categorizable patients) | |||||
Patients, n (%) | 43 (25.7) | 8 (5.4) | 2 (1.2) | 5 (3.0) | <0.01 |
Age, years | 54 (38–70) | 71 (64–78) | 54 (52–56) | 74 (73–82) | 0.01 |
Female sex, % | 46.5 | 50 | 100 | 40.0 | 0.79 |
Hypertension, % | 32.6 | 25.0 | 50 | 100 | 0.02 |
Diabetes mellitus, % | 25.6 | 50.0 | 100 | 60.0 | 0.18 |
Ischemic heart disease, % | 7.0 | 0.0 | 100 | 80.0 | <0.01 |
APACHE II score | 25 (16–33) | 33 (30–35) | 28 (11–44) | 22 (19–30) | 0.64 |
SOFA score on admission | 9 (7–11) | 10 (9–12) | 9 (7–11) | 7 (7–7) | 0.22 |
Percentage on vasopressors during hospitalization | 70.0 | 87.5 | 50.0 | 60.0 | 0.53 |
BMI, kg/m2 | 27.2 (21.8–36.5) | 28.9 (22.1–34.5) | 32.3 (28.8–35.9) | 28.7 (28.0–36.4) | 0.70 |
E, cm/second | 90.1 (77.3–102.5) | 57.2 (50.8–93.1) | 62.2 (54.1–70.4) | 113.6 (112.3–130.5) | <0.01 |
A, cm/second | 74.8 (63.3–92.2) | 85.3 (83.9–96.2) | 68.6 (59.2–78.0) | 34.4 (27.0–41.8) | 0.05 |
e′, cm/second | 9.8 (9.0–11.0) | 7.0 (5.7–8.6) | 7.3 (7.3–7.3) | 7.0 (6.1–7.2) | <0.01 |
E/e′ | 9.1 (7.6–10.3) | 8.1 (7.9–9.4) | 9.7 (9.7–9.7) | 15.5 (14.6–21.9) | <0.01 |
DT, milliseconds | 180 (158–211) | 238 (229–282) | 180 (180–180) | 142 (121–147) | <0.01 |
E/A | 1.21 (1.04–1.39) | 0.67 (0.54–0.87) | 0.91 (0.90–0.91) | 3.76 (2.69–4.84) | <0.01 |
LAVI, ml/m2 | 23.7 (15.8–29.6) | 55.6 (34.3–59.0) | 35.2 (35.2–35.2) | 34.7 (34.3–56.5) | <0.01 |
Ejection fraction | 60 (52–70) | 75 (72–75) | 55 (50–59) | 62 (60–65) | 0.01 |
ICU-free days | 25.4 (21.3–26.4) | 24.8 (19.3–25.4) | 25.1 (54.6–25.5) | 24.0 (23.2–25.4) | 0.42 |
Mortality, % | 27.9 | 37.5 | 100 | 60.0 | 0.41 |
IVF administered in 6 h prior to TTE, ml | 1231 (600–2000) | 714 (141–2005) | 633 (633–633) | 1000 (1000–1000) | 0.75 |
IVF administered in 6 h after TTE, ml | 1200 (575–2085) | 500 (105–1486) | 1068 (435–1700) | 371 (100–1126) | 0.40 |
Simplified definition (n = 146 categorizable patients) | |||||
Patients, n (%) | 50 (34.2) | 3 (2.1) | 37 (25.3) | 56 (38.4) | <0.01 |
Median age, years | 55 (42–70) | 86 (70–87) | 60 (54–74) | 72 (63–77) | <0.01 |
Female sex, % | 46.0 | 66.7 | 35.1 | 64.3 | 0.03 |
Hypertension, % | 38.0 | 100 | 59.5 | 73.2 | <0.01 |
Diabetes mellitus, % | 24.0 | 100 | 24.3 | 57.1 | <0.01 |
Ischemic heart disease, % | 10.0 | 100 | 13.5 | 41.1 | <0.01 |
APACHE II score | 26 (17–34) | 36 (33–37) | 25 (16–31) | 23 (19–29) | 0.19 |
SOFA score | 9 (6–10) | 9 (7–11) | 9 (7–12) | 7 (5–9) | 0.07 |
Percentage on vasopressors during hospitalization | 54.0 | 33.3 | 37.8 | 32.1 | 0.12 |
BMI, kg/m2 | 27 (22–35) | 23 (16–34) | 28 (23–32) | 28 (24–34) | 0.71 |
E, cm/second | 92.1 (80.4) | 55.7 (36.7–58.1) | 71.1 (58.6–77.7) | 101.9 (87.1–117.1) | <0.01 |
A, cm/second | 78.4 (65.8–96.2) | 89.3 (67–102.8) | 93.5 (76.8–120.1) | 93.5 (76.8–120.1) | 0.02 |
e′, cm/second | 9.5 (8.6–10.7) | 7.0 (6.0–7.4) | 6.7 (6.0–7.3) | 5.8 (4.7–6.4) | 1.00 |
E/e′ | 9.3 (7.9–11.4) | 7.8 (6.1–7.9) | 10.0 (9.6–11.6) | 17.7 (14.7–20.6) | <0.01 |
DT, milliseconds | 181 (161–211) | 229 | 208 (191–237) | 189 (149–218) | 0.05 |
E/A | 1.2 (1.0–1.4) | 0.7 (0.4–0.8) | 0.8 (0.7–1.0) | 1.0 (0.7–1.3) | <0.01 |
LAVI, ml/m2 | 23.7 (16.2–30.9) | 16.6 (166–16.6) | 21.0 (16.6–25.1) | 25.3 (19.1–31.9) | 0.18 |
Ejection fraction | 62 (56–70) | 67 (55–75) | 61 (50–70) | 60 (45–70) | 0.52 |
ICU-free days | 25 (22–26) | 21 (21–25) | 25 (24–26) | 25 (24–26) | 0.23 |
Mortality, % | 26.0 | 100 | 21.6 | 23.2 | 0.08 |
IVF administered in 6 h prior to TTE, ml | 1235 (481–2175) | 593 (141–1045) | 929 (245–2000) | 1000 (212–1173) | 0.27 |
IVF administered in 6 h after TTE, ml | 1284 (388–2092) | 580 (500–5157) | 472 (196–1050) | 588 (300–1321) | 0.05 |