From: Acute kidney injury in critically ill cancer patients: an update
Reference | Multicenter (Yes/No) | Type of cancer | Population | Reasons for admission to ICU | Definition of AKI | Incidence of AKI | Cause(s) of AKI/contributing factors | Survival/mortality of AKI cancer patients (%) | Survival/mortality of non-AKI cancer patients (%) | Indications for RRT | RRT modality | Long-term prognosis for AKI patients |
---|---|---|---|---|---|---|---|---|---|---|---|---|
[46] | No | Hemato | 537 with induction chemo | - | 50Â % rise in SCr above baseline RIFLE | 36Â % RIFLE R: 15Â % I: 10Â % F: 11Â % | ? | Mortality RIFLE R: 13.6Â % I: 19.6Â % F: 61.7Â % | Mortality: 4Â % | Indications? RRT: 8Â % | ? | Â |
[48] | No | Hemato | 344 | Infections/noninfectious complications | ? | 16.6Â % | ? | ? | ? | ? | Â | Â |
[47] | No | Hemato | 94 | Severe sepsis/shock: 71Â % Renal failure: 17Â % Respiratory failure: 12Â % | Need for RRT RIFLE | RIFLE R:7Â % I: 33Â % F: 60Â % | Septic AKI: 54Â % Nonseptic AKI: 46Â % Nephrotoxic drugs: 15/94 Hypovolemic: 13/94 TLS: 11/94 | 23.5Â % survival | - | Â | CVVHDF/CVVHF | 23Â % of survivors persistent AKI after ICU discharge |
[32] | No | All | 3795 medical/surgical pts | Oncology ICU Not specified | Assess link to outcome of increases of SCr cfr RIFLE | 21.8 % RIFLE R: 12.5 % I: 4.9 % F: 4.5 % | Multiple | Creat rise: 10 %: Mortality: 15–25 %; Creat rise 25 %: | ? | ? RRT: 19 % in nonsurvivors, 1.6 % in survivors | ? | ? |
Mortality: 14–30 % Rise in SCr of 25 % (≥48 h) Mortality: 36 % | No rise in SCr of 25 % for ≥ 48 h: Mortality: 15 % | |||||||||||
[40] | Yes | All | All AKI 773 pts Ca pts: 118 (15.2Â %) Solid cancer: 73Â % Hemato: 27Â % | Serious comorbidities | RIFLE before start of RRT | 118/773 100Â % AKI RIFLE R: 25Â % I: 24Â % F: 52Â % | Sepsis: 78Â % Ischemia/shock: 74Â % Toxins/contrast: 32Â % | Ca pts hospital survival: 12Â % of all survivors Non Ca pts hospital survival: 7Â % of all survivors Overall survival: 30Â % | - | Azotemia: 58Â % Fluid overload: 55Â % Acidosis: 48Â % | CRRT: 89Â % | ? |
[45] | No | Hemato | 199 pts onco | Oncology ICU Respiratory failure: 33Â % Postoperative: 20Â % Sepsis: 21.1Â % | ? Need for RRT? | 8Â % on ICU admission | ? | RRT survivors: 38Â % RRT nonsurvivors: 62Â % | ? | 79 (40.9Â %) | ? | ? |
[44] | No | All | 477 ca pts | ICU surgical pts | AKIN criteria | 10.3Â % on ICU admission | Post surgery | Hospital mortality: 13Â % ICU mortality: 10.9Â % | Hosp mortality: 1.5Â % ICU mortality: 1Â % | ? | ? | ? |
[6] | No | All | 563 ca pts with sepsis Solid cancer: 77Â % Hemato: 23Â % | Sepsis | ? Need for RRT? | 20Â % on RRT | Sepsis | ? Overall mortality: ICU: 51Â % Hospital: 65Â % 6Â month: 72Â % | ? | ? | ? | ? |
[11] | No | Hemato | 200 pts | Start chemo 1Â day before ICU See [73] | RIFLE | Total:68.5Â % RIFLE R: 27Â % I: 19.7Â % F: 53.3Â % | Prerenal: 48.2Â % TLS: 43.8Â % ATN: 28.5Â % Nephrotoxicity: 20.4Â % Multiple causes: 45.3Â % | ICU mortality: 35Â % Hospital mortality: 35Â % | ICU mortality: 7.9Â % Hospital mortality: 19.1Â % | ? 52.7Â % RRT (during ICU) | IHD: 63.8Â % CRRT: 19.4Â % Both: 16.6Â % | Complete hemato remission At 6Â months AKI: 39.4Â % Non AKI: 68.3Â % |
[42] | No | All | 162 ca pts Solid cancer: 104 Hemato: 35.8Â % | Septic shock: 66.7Â % Respiratory failure: 63.6Â % | ? Need for RRT? | AKI: 30Â % Hemato: 41Â % Solid cancer: 23Â % | ? | Mortality AKI:26Â % | Â | Total RRT: 33Â % Hemato: 38Â % Solid cancer: 30Â % | ? | ? |
[43] | No | All | 56 pts with chemo | Chemo | ? | 16Â % Hospital nonsurvivors: 13Â % Hospital survivors: 18Â % | ? | ? | Â | 39Â % | CVVHF | ? |
[33] | Yes | All | Hemato: 1741 Solid tumors: 602 | Not specified | ? | Hemato: 20Â % Solid cancer: 11Â % | ? | ? | ? | Â | Â | Â |
[30] | Yes | All | Ca pts: 357 (19.8Â % of all admissions) AKI-EPI study | Multiple | KDIGO | 59Â % | ? | ? | ? | ? | ? | ? |
[41] | Yes | Hemato | Neutropenic pts: 289 | Sepsis: 80Â % Acute respiratory failure: 64Â % Shock: 58Â % | ? Need for RRT? | 18Â % | ? | 19.85Â % mortality | ? | ? | ? | ? |
[39] | Yes | Hemato | Hemato: 1009 | Acute respiratory failure: 62.4Â % Shock: 42.4Â % AKI: 30.5Â % Coma: 22.3Â % Urgent chemo: 6.9Â % | AKIN | During ICU stay: 66.5Â % AKIN1: 38.4Â % AKIN2: 11.2Â % AKIN3: 50.4Â % | Nephrotoxic agents:25.3Â % Sepsis/shock: 31.3Â % | Hospital mortality: 44.3Â % AKIN stage dependent | Hospital mortality: 25.4Â % | RRT: 271 (26.9Â %) RRT-AKIN AKIN1: 19.6Â % AKIN2: 9.9Â % AKIN3: 64.2Â % | CRRT: 136 pts IHD: 135 pts | 12.9Â % of survivors RRT dependent |