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Table 4 Receiver operating characteristic curve analysis to determine the optimum cutoff value of the different biomarkers on day 0 for the prediction of infection (groups 2 + 3)

From: The intensive care infection score – a novel marker for the prediction of infection and its severity

 

Parameters

Biomarkers

AUROC (95 % CI)

P

Cutoff

Sensitivity

Specificity

PPV

NPV

WBC (109/L)

0.53 (0.46, 0.60)

0.38

12.9

0.54

0.54

0.55

0.54

CRP (mg/L)

0.70 (0.64, 0.76)

<0.001

111

0.65

0.64

0.65

0.64

PCT (μg/L)

0.71 (0.66, 0.77)

<0.001

1.41

0.65

0.66

0.66

0.65

ICIS

0.73 (0.67, 0.79)

<0.001

5

0.66

0.71

0.70

0.67

  1. Abbreviations: AUROC area under the receiver operating characteristic curve, CI confidence interval, CRP C-reactive protein, ICIS intensive care infection score, PCT procalcitonin, PPV positive predictive value, NPV negative predictive value, WBC white blood cells. The AUROC for ICIS differed from that for WBC (P < 0.001)
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Critical Care

ISSN: 1364-8535