From: Lactic acidosis and severe septic shock in metformin users: a cohort study
Variable | All patients | Metformin users | Metformin nonusers |
---|---|---|---|
N = 162 | n = 44 | n = 118 | |
Age (1 year↑) | 1.05 (1.02–1.08)P | 0.99 (0.95–1.02) | 1.05P (1.0–1.08) |
Gender (male) | 0.83 (0.58–1.18) | 0.67 (0.30–1.14) | 0.88 (0.59–1.32) |
Diabetes | 0.50 (0.34–0.74)P | --- | 0.82 (0.48–1.40) |
Hypertension | 0.79 (0.55–1.14) | 0.47 (0.19–1.14) | 1.12 (0.74–1.65) |
IHD | 1.22 (0.83–1.78) | 0.88 (0.37–2.06) | 1.55P (1.01–2.4) |
Cerebrovascular attack | 1.09 (0.72–1.65) | 1.57 (0.69–3.50) | 1.15 (1.01–2.40) |
Lactate (1 mg/dL↑) | 1.06 (0.99–1.10) | 1.04 (0.96–1.16) | 1.05 (0.99–1.11) |
pH | 0.91 (0.37–2.26) | 1.02 (0.16–6.45) | 1.05 (0.99–1.11) |
Bicarbonate (1 meq/L↑) | 0.97 (0.93–1.01) | 0.99 (0.92–1.06) | 0.97 (0.93–1.01) |
APACHE II (1↑) | 1.03 (0.99–1.07) | 1.10 (1.01–1.20)P | 0.99 (0.95–1.04) |
Acute kidney injury | 0.93 (0.62–1.40) | 0.80 (2.37–2.68) | 0.91 (0.54–1.50) |
Creatinine (1 mg/dL↑) | 0.92 (0.82–1.00) | 0.91 (0.75–1.11) | 1.08 (0.92–1.29) |
Anion gap (1↑) | 0.99 (0.97–1.01) | 0.98 (0.94–1.02) | 1.01 (0.98–1.04) |
HD | 0.61 (0.40–0.95)P | 0.46 (0.19–1.11) | 0.91 (0.54–1.50) |
Temperature (1 °C) | 0.94 (0.63–1.40) | 0.89 (0.55–1.34) | 0.98 (0.67–1.45) |
Metformin | 0.42 (0.27–0.66)P | --- | --- |
Metformin adj* | 0.21 (0.05–0.94)P | --- | --- |