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Table 2 Hazard ratios and confidence intervals for inhospital mortality

From: Lactic acidosis and severe septic shock in metformin users: a cohort study

Variable

All patients

Metformin users

Metformin nonusers

N = 162

n = 44

n = 118

Age (1 year↑)

1.05 (1.02–1.08)P

0.99 (0.95–1.02)

1.05P (1.0–1.08)

Gender (male)

0.83 (0.58–1.18)

0.67 (0.30–1.14)

0.88 (0.59–1.32)

Diabetes

0.50 (0.34–0.74)P

---

0.82 (0.48–1.40)

Hypertension

0.79 (0.55–1.14)

0.47 (0.19–1.14)

1.12 (0.74–1.65)

IHD

1.22 (0.83–1.78)

0.88 (0.37–2.06)

1.55P (1.01–2.4)

Cerebrovascular attack

1.09 (0.72–1.65)

1.57 (0.69–3.50)

1.15 (1.01–2.40)

Lactate (1 mg/dL↑)

1.06 (0.99–1.10)

1.04 (0.96–1.16)

1.05 (0.99–1.11)

pH

0.91 (0.37–2.26)

1.02 (0.16–6.45)

1.05 (0.99–1.11)

Bicarbonate (1 meq/L↑)

0.97 (0.93–1.01)

0.99 (0.92–1.06)

0.97 (0.93–1.01)

APACHE II (1↑)

1.03 (0.99–1.07)

1.10 (1.01–1.20)P

0.99 (0.95–1.04)

Acute kidney injury

0.93 (0.62–1.40)

0.80 (2.37–2.68)

0.91 (0.54–1.50)

Creatinine (1 mg/dL↑)

0.92 (0.82–1.00)

0.91 (0.75–1.11)

1.08 (0.92–1.29)

Anion gap (1↑)

0.99 (0.97–1.01)

0.98 (0.94–1.02)

1.01 (0.98–1.04)

HD

0.61 (0.40–0.95)P

0.46 (0.19–1.11)

0.91 (0.54–1.50)

Temperature (1 °C)

0.94 (0.63–1.40)

0.89 (0.55–1.34)

0.98 (0.67–1.45)

Metformin

0.42 (0.27–0.66)P

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Metformin adj*

0.21 (0.05–0.94)P

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  1. Univariate analyses are presented for the investigated variables. A multivariate analysis is presented for metformin use
  2. IHD ischemic heart disease, HD underwent hemodialysis, APACHE II acute physiology and chronic health evaluation II.
  3. PRefers to p <0.05
  4. *Adjusted for age, gender, diabetes, hypertension, ischemic heart disease, cerebrovascular disease, malignancy, levels of creatinine and lactate at admission, and APACHE II score