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Fig. 1 | Critical Care

Fig. 1

From: Estrogen administered after cardiac arrest and cardiopulmonary resuscitation ameliorates acute kidney injury in a sex- and age-specific manner

Fig. 1

Cardiac arrest and cardiopulmonary resuscitation (CA/CPR) caused renal injury in a sex- and age-specific manner. Blood and tissue samples were collected 24 h after CA/CPR in young (10–15 weeks) or middle-aged (43–48 weeks) male or female mice. CA/CPR caused renal injury in a sex- and age- specific manner. In young animals, female sex reduced serum urea nitrogen (a), serum creatinine (b), and necrotic tubules (c). In middle-aged animals, female sex reduced serum urea nitrogen (a) and serum creatinine (b) but not necrotic tubules (c). Data are presented as mean ± standard deviation, n = 6–10 per group. *P < 0.05 versus same age different sex, # P < 0.05 versus same sex different age. Data were analyzed by using two-way analysis of variance with post hoc Sidak’s test. Aging did not alter baseline renal function in naïve mice; therefore, we combined young and middle age naïve mice

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Critical Care

ISSN: 1364-8535