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Table 3 Annual incidence of hospitalizations with suspected infection and organ dysfunction (codes or clinical markers) in 2005 versus 2013

From: Improving documentation and coding for acute organ dysfunction biases estimates of changing sepsis severity and burden: a retrospective study

 

Organ dysfunction codes

Objective clinical markers of organ dysfunction

 

2005

2013

Fitted 9-year relative change (95 % CI)

p value for linear trend

2005

2013

Fitted 9-year relative change (95 % CI)

p value for linear trend

Per/10,000 (Total cases)

Per/10,000 (Total cases)

Per/10,000 (Total cases)

Per/10,000 (Total cases)

Shock

65 (580)

271 (1787)

+229 % (+176, 282 %)

<0.001

465 (4127)

586 (5279)

+29 % (+16, 42 %)

0.007

Respiratory

171 (1516)

248 (2234)

+55 % (44, 66 %)

<0.001

330 (2933)

314 (2831)

−6.9 % (−8.6, −5.1 %)

<0.001

Renal

322 (2857)

547 (4924)

+81 % (+74, 87 %)

<0.001

354 (3144)

260 (2338)

−27 % (−53, −0.5 %)

0.103

Acidosis

54 (479)

151 (1356)

+187 % (+169, 205 %)

<0.001

76 (673)

80 (722)

+0.6 % (−5.2, +6.5 %)

0.837

Hepatic

26 (232)

42 (381)

+65 % (+47, 83 %)

<0.001

90 (797)

107 (962)

+17 % (−1.6, +36 %)

0.133

Coagulopathy

32 (287)

37 (334)

+39 % (+0.1, 77 %)

0.106

116 (1033)

106 (954)

+4.7 % (−8.2, +18 %)

0.507

Thrombocytopenia

106 (940)

150 (1351)

+51 % (+15, 87 %)

0.039

187 (1657)

264 (2382)

+50 % (+37, 64 %)

<0.001

  1. CI confidence interval