Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis

van Zanten, Arthur R. H.; Dhaliwal, Rupinder; Garrel, Dominique; Heyland, Daren K.

doi:10.1186/s13054-015-1002-x

Critical Care

Table 3 Excluded randomized studies of enteral glutamine supplementation in critically ill patients

From: Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis

Author	Year	Reasons for exclusion	References
Jebb et al.	1995	Transplant and/or elective surgery patients	[34]
Long et al.	1995	No clinical outcomes	[35]
Jensen et al.	1996	No clinical outcomes	[36]
Fish et al.	1997	Cancer patients	[37]
Scolapio et al.	1997	Crossover design	[38]
Anderson et al.	1998	Surgical patients	[39]
Anderson et al.	1998	Pediatric cancer patients	[40]
Den Hond et al.	1999	Not ICU patients	[41]
Schloerb and Skikne	1999	Cancer and/or surgery patients	[42]
Scolapio	1999	Crossover design	[43]
Zhou et al.	1999	Earlier study of 2003 RCT already included	[44]
Jackson et al.	2000	Surgery patients, no clinical outcomes	[45]
Szkudlarek et al.	2000	Crossover design	[46]
Chen et al.	2001	No clinical outcomes	[47]
Scolapio et al.	2001	Crossover design	[48]
Velasco et al.	2001	No clinical outcomes, duplicate of Houdijk et al. study [24]	[49]
Boelens et al.	2002	No clinical outcomes	[50]
Novak et al.	2002	Studies on critically ill patients were included in this review	[51]
Flaring et al.	2003	Elective surgery patients	[52]
García-de-Lorenzo et al.	2003	Systematic review, Individual studies were included in this review	[53]
Boelens et al.	2004	Duplicate of Houdijk et al. study [24]	[54]
Falcao de Arruda et al.	2004	Includes probiotics	[55]
Peng et al.	2005	Duplicate study of earlier publication already [30] included	[56]
Peng et al.	2006	Duplicate of a previous study [30]	[57]
Guo et al.	2007	No clinical outcomes	[58]
Kuhls et al.	2007	Too many interventions	[59]
Spindler-Vesel et al.	2007	Too many interventions: RCT of GLN vs. fiber vs. peptide vs. fiber + synbiotics	[60]
Beale et al.	2008	Non-isonitrogenous intervention including arginine and glycine	[61]
Han et al.	2012	Elective surgery patients	[62]
Cavalcante et al.	2012	No clinical outcomes, crossover design	[63]
Han et al.	2014	No clinical outcomes	[64]
Koksal et al.	2014	Only duration of mechanical ventilation reported	[65]

GLN glutamine, ICU intensive care unit, RCT randomized controlled trial

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ISSN: 1364-8535

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