Skip to main content

Table 3 Comparison of Aspergillus-specific lateral-flow device test and conventional bronchoalveolar lavage culture performance for diagnosing probable or proven versus no invasive pulmonary aspergillosisa

From: Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients

Probable or proven IPA versus no IPA

LFD

Conventional BAL culture

Sensitivity

80% (16/20)

50% (10/20)

Specificity

81% (88/108)

85% (88/103)

PPV

44% (16/36)

40% (10/25)

NPV

96% (88/92)

90% (88/98)

DOR (95% CI)

17.6 (5.3 to 58.3)

5.9 (2.1 to 16.5)

  1. aBAL, Bronchoalveolar lavage; CI, Confidence interval; DOR, Diagnostic odds ratio; IPA, Invasive pulmonary aspergillosis; LFD, Aspergillus-specific lateral-flow device test; NPV, Negative predictive value; PPV, Positive predictive value. According to European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria [34], probable IPA cases require mycological evidence by positive Aspergillus spp BAL culture, cytology, microscopy or positive galactomannan tests, in addition to host factors and clinical criteria.
Back to article page

Critical Care

ISSN: 1364-8535