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Table 3 Lung inflammatory and fibrotic response

From: Open lung approach associated with high-frequency oscillatory or low tidal volume mechanical ventilation improves respiratory function and minimizes lung injury in healthy and injured rats

  

UI

SW

LPS

TNF-α

LP-CMV

5.9 (4.6/7.8)

2.3 (1.9/2.9)

13.1 (12.2/15.5)

 

BP-CMV

6.0 (4.9/7.4)

2.8 (2.9/3.0)

21.1 (12.8/24.1)c

 

HFOV

6.5 (3.7/7.4)

3.5 (1.8/4.0)

12.7 (11.6/15.6)

Interleukin-1β

LP-CMV

6.4 (4.6/7.5)

2.9 (2.4/6.1)a,b

8.4 (7.6/9.9)

 

BP-CMV

4.5 (3.5/6.6)

2.2 (1.5/3.0)*

10.4 (8.3/11.1

 

HFOV

4.3 (3.7/5.9)

2.2 (1.8/3.2)*

9.5 (8.4/11.2)

Interleukin-6

LP-CMV

24.0 (10.2/30.5)

625.2 (399.8/880.0)a,b

1278.5 (1187.4/1390.2)a,b

 

BP-CMV

16.0 (6.7/23.7)

380.7 (205.4/417.5)

498.4 (381.2/568.2)

 

HFOV

5.7 (3.6/14.7)

367.4 (182.9/496.1)

446.1 (252.6/563.8)

Procollagen I

LP-CMV

1.0 (0.8/1.2)*a

0.5 (0.6/0.8)*

0.4 (0.3/0.4)

 

BP-CMV

1.4 (1.1/2.0)c

0.6 (0.5/1.2)*

0.2 (0.1/0.4)

 

HFOV*

1.0 (0.7/1.5)*

0.8 (0.4/1.0)*

0.3 (0.3/0.5)

Procollagen III

LP-CMV

0.5 (0.5/0.6)

0.3 (0.2/0.4)

0.2 (0.1/0.2)

 

BP-CMV

0.6 (0.5/0.8)

0.3 (0.2/0.3)

0.2 (0.1/0.3)

 

HFOV

0.5 (0.4/0.6)

0.3 (0.2/0.3)

0.2 (0.2/0.3)

  1. UI, uninjured; SW, lung injury induced by saline washout; LPS, lung injury induced by intraperitoneal/intravenous E. coli lipopolysaccharide; LP-CMV, controlled mechanical ventilation with low PEEP; BP-CMV, controlled mechanical ventilation with "best" PEEP; HFOV, high frequency oscillatory ventilation. Values are medians and interquartile (25%-75%) range and are presented as fold changes relative to unventilated control group. *P > 0.05 vs. unventilated control group. aP < 0.05 LP-CMV vs. BP-CMV. bP < 0.05 LP-CMV vs. HFOV. cP < 0.05 BP-CMV vs. HFOV.