| Â | UI | SW | LPS |
|---|
| Â | LP-CMV | BP-CMV | HFOV | LP-CMV | BP-CMV | HFOV | LP-CMV | BP-CMV | HFOV |
|---|
Pinsp | 11.8 ± 1.0 | 12.8 ± 2.0 | 12.4 ± 0.9 | 26.1 ± 2.0 | 25.6 ± 1.3 | 27.0 ± 2.5 | 11.2 ± 0.9 | 10,5 ± 0.8 | 11.3 ± 0.5 |
Estat,RS | 2.7 ± 0.5 | 2.7 ± 0.5 | 2.8 ± 0.3 | 6.4 ± 1.1 | 6.3 ± 0.7 | 6.8 ± 1.1 | 2.9 ± 0.3 | 2.8 ± 0.4 | 3.0 ± 0.4 |
PaO2/FiO2 | 504.0 ± 17.4 | 481.5 ± 44.7 | 482.8 ± 70.6 | 73.1 ± 19.9 | 76.8 ± 17.9 | 78.0 ± 13.7 | 477.2 ± 48.6 | 428.5 ± 80.1 | 458.4 ± 33.3 |
PaCO2 | 46.2 ± 5.3 | 39.2 ± 8.0 | 46.8 ± 5.7 | 56.6 ± 7.2 | 63.0 ± 7.2 | 53.8 ± 10.1 | 45.0 ± 8.2 | 44.7 ± 15.7 | 49.0 ± 8.1 |
- UI, uninjured; SW, lung injury induced by saline washout; LPS, lung injury induced by intraperitoneal/intravenous E. coli lipopolysaccharide; BL, baseline measurements; LP-CMV, controlled mechanical ventilation with low PEEP; BP-CMV, controlled mechanical ventilation with "best" PEEP; HFOV, high frequency oscillatory ventilation; Pinsp, End-inspiratory plateau pressures at baseline; Estat, RS, Respiratory system elastance (Estat, RS) at baseline; PaO2/FiO2, PaO2/FiO2 index at baseline; PaCO2, PaCO2 at baseline. Values are means ± standard deviation. No significant differences were noted in the respective treatment groups at baseline. UI, uninjured; SW, lung injury induced by saline washout; LPS, lung injury induced by intraperitoneal/intravenous E. coli lipopolysaccharide.
