Table 2 Pharmacokinetic parameters of the β-lactams
From: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
Vd (L/kg) | Cmax (μg/mL) | AUC (mg.h/mL) | CL (mL/min.kg) | t1/2 (hours) | |
|---|---|---|---|---|---|
Piperacillin-tazobactam (n = 27) | 0.38 (0.29-0.43) | 123 (72-179) | 469 (196-896) | 2.02 (1.33-4.26) | 2.58 (1.51-3.84) |
Meropenem (n = 16) | 0.43 (0.31-0.77) | 35 (29-46) | 132 (91-179) | 1.87 (1.23-2.63) | 2.05 (1.66-3.36) |
Ceftazidime (n = 18) | 0.48 (0.36-0.71) | 63 (48-78) | 522 (392-634) | 0.89 (0.63-1.34) | 5.84 (4.13-7.39) |
Cefepime (n = 19) | 0.36 (0.33-0.44) | 68 (51-86) | 310 (234-422) | 1.26 (1.07-1.95) | 3.37 (2.26-5.34) |