Multiple organ dysfunction | Sepsis severity | ICU mortality | ||||
---|---|---|---|---|---|---|
Patient characteristics Median (quartiles) or % | Non-MODS (n = 86) | MODS (n = 121) | Severe sepsis (n = 118) | Septic shock (n = 89) | Survivors (n = 129) | Non-survivors (n = 78) |
Demographics | ||||||
Age (years) | 58.5 (48-68)* | 70 (59-77)* | 61 (51-71)* | 72 (59-77)* | 61 (50-70)* | 72.5(61-79)* |
Male sex, % | 45.3 | 53.7 | 46.6 | 55.1 | 45.0 | 59.0 |
Previous or preexisting conditions | ||||||
Days of complaint before admission, (days) | 4 (2-7) | 4 (1-10) | 4 (2-8) | 4 (1-9) | 4 (1-7.5) | 4 (2-10) |
Pulmonary hospitalisation in the past two years, % | 27.9 | 24.8 | 31.4* | 19.1* | 27.9 | 23.1 |
Cachexia, % | 12.8 | 17.4 | 12.7 | 19.1 | 14.0 | 17.9 |
Nosocomial pneumonia, % | 25.6* | 44.6* | 30.5* | 44.9* | 32.6 | 43.6 |
Ischemic heart disease, % | 33.7 | 43.8 | 37.3 | 42.7 | 36.4 | 44.9 |
COPD, % | 43.0 | 33.1 | 42.4 | 30.3 | 39.5 | 33.3 |
Hypertension, % | 55.8 | 62.8 | 59.3 | 60.7 | 58.1 | 62.8 |
Diabetes mellitus, % | 24.4 | 27.3 | 26.3 | 25.8 | 24.0 | 29.5 |
Active and ever (>15 years) smoking, % | 46.5 | 42.1 | 46.6 | 40.4 | 46.5 | 39.7 |
Alcohol consumption >1 glass/day, % | 9.3 | 13.2 | 9.3 | 14.6 | 10.9 | 12.8 |
ICU conditions | ||||||
28 days mortality, % | 0.0* | 62.8* | 9.3* | 73.0* | 0.0* | 97.4* |
ICU mortality, % | 0.0* | 64.5* | 9.3* | 75.3* | - | - |
APACHE II score at admission | 18 (14-22)* | 24 (18.5-30.5)* | 19 (15-23)* | 25 (20-31)* | 19 (15-23)* | 25 (22-31)* |
DIC score at admission | 0 (0-2)* | 3 (0-4)* | 0 (0-2)* | 3 (2-5)* | 0 (0-2)* | 3 (2-4)* |
ICU length of stay, (days) | 8 (5-12) | 8 (5-16.5) | 8 (5-12) | 8 (4.5-16.5) | 9 (5-15) | 8 (4-12) |
Horowitz quotient of invasively ventilated patients, (PaO2/FiO2) | 269.0 (161.3-342.3)* | 179.6 (126.2-232.4)* | 222.0 (149.9-335.4)* | 175.2 (119.7-229.7)* | 197.5 (139.1-305.5) | 188.3 (124.2-241.6) |
ARDS, % | 7.0* | 24.0* | 8.5* | 28.1* | 11.6* | 25.6* |
Invasive ventilation, % | 52.3* | 97.5* | 62.7* | 100.0* | 65.9* | 100.0* |
Length of invasive ventilation, (days) | 5 (3.5-7.5)* | 8 (4-13.3)* | 5.5 (4-10.3) | 7 (4-14) | 6 (4-13) | 7 (4-12) |
Tracheotomy, % | 5.8* | 14.9* | 10.2 | 12.4 | 10.9 | 11.5 |
Hemodialysis, % | 7.0* | 17.4* | 9.3 | 18.0 | 9.3* | 19.2* |
Infection types | ||||||
Unconfirmed, % | 55.8* | 31.4* | 49.2* | 31.5* | 45.0 | 35.9 |
Confirmed, % | ||||||
Gram positive | 10.5 | 19.3 | 11.7 | 21.3 | 15.5 | 18.0 |
Gram negative | 52.6 | 57.8 | 60.0 | 52.5 | 52.1 | 62.0 |
Atypical pneumonia (Chlamydia, Mycoplasma, Legionella) | 23.7 | 14.5 | 18.3 | 16.4 | 21.1 | 12.0 |
Mixed | 13.2 | 8.4 | 10.0 | 9.8 | 11.3 | 8.0 |