Table 1 Simulated scenarios for sample size determination in the design of a hypothetical study
From: Delta inflation: a bias in the design of randomized controlled trials in critical care medicine
| Â | Standard Scenario | Relaxed significance level | Relaxed Power | Baseline Mortality shifted away from 50% | Inflated delta |
|---|---|---|---|---|---|
Significance level (two-sided) | 0.05 | 0.1 | 0.05 | 0.05 | 0.05 |
Power | 90% | 90% | 80% | 90% | 90% |
Baseline (placebo) mortality rate | 50% | 50% | 50% | 40% | 50% |
Delta (ARR) | 10% | 10% | 10% | 10% | 15% |
Required sample size | 1076 | 884 | 816 | 992 | 480 |