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Table 2 Baseline characteristics of the patients with normal kidney function and RIFLE class 'risk' on admission broken by HES administration

From: Resuscitation with low volume hydroxyethylstarch 130 kDa/0.4 is not associated with acute kidney injury

 

Normal kidney function on admission

P

RIFLE 'risk' on admission

P

 

HES -

n = 45

HES +

n = 28

 

HES -

n = 54

HES +

n = 37

 

Age (years) (mean ± SD)

59.5 ± 15.9

55.8 ± 17.2

0.4

66.2 ± 13.3

64.1 ± 15.8

0.78

Male sex n(%)

32 (71.1)

20 (71.4)

0.98

41 (75.9)

26 (70.2)

0.55

Comorbidities

      

Chronic cardiac failure

7 (15.5)

3 (10.7)

0.73

12 (22.2)

5 (13.5)

0.29

More than one cardiovascular event

6 (13.3)

4 (14.3)

1

13 (24)

5 (13.5)

0.21

Diabete mellitus

14 (31.1)

5 (17.9)

0.2

10 (18.5)

10 (27)

0.34

COPD

13 (28.9)

8 (28.6)

0.98

16 (29.6)

12 (32.4)

0.77

Chronic liver failure

7 (15.5)

1 (3.6)

0.14

2 (3.7)

0 (0)

0.51

Chronic alcoholism

8 (17.8)

6 (21.4)

0.7

10 (18.5)

10 (27)

0.34

Chronic renal failure

2 (4.4)

2 (7.1)

0.63

3 (5.5)

3 (8.1)

0.63

Non hematologic malignancy

2 (4.4)

6 (21.4)

0.05

3 (5.5)

2 (5.4)

1

Hematologic malignancy

2 (4.4)

1 (3.6)

1

1 (1.8)

0 (0)

1

Immunosuppression

7 (15.5)

3 (10.7)

0.73

6 (11.1)

2 (5.4)

0.47

Usual treatments

      

ACE inhibitors/ARB

14 (31.1)

6 (21.4)

0.37

21 (38.9)

15 (40.5)

0.93

Diuretics

15 (33.3)

3 (10.7)

0.05

17 (31.5)

10 (27)

0.6

NSAIDs

2 (4.4)

0 (0)

0.52

3 (5.5)

1 (2.7)

0.64

Hospitalisation before ICU

19 (42.2)

12 (43)

0.96

24 (44.4)

10 (27)

0.09

Reason for ICU admission

  

0.07

  

0.56

Medicine

41 (91.1)

19 (68)

 

47 (87)

31 (83.8)

 

Planned surgery

1 (2.2)

3 (14.3)

 

0 (0)

0 (0)

 

Urgent surgery

2 (4.4)

4 (10.7)

 

6 (11.1)

6 (16.2)

 

Polytrauma

1 (2.2)

2 (7.1)

 

1 (1.8)

0 (0)

 

Clinical presentation

      

SAPS II

40.3 ± 15.9

46 ± 19.5

0.32

40.6 ± 14.6

50.3 ± 13.1

0.001

SOFA

6.1 ± 3.6

8.2 ± 3.9

0.03

6.5 ± 3.3

8.4 ± 2.3

0.001

SIRS - sepsis

14 (31.1)

9 (32.1)

0.92

22 (40.7)

11 (29.7)

0.28

Septic shock

8 (17.8)

9 (32.1)

0.16

17 (31.5)

17 (45.9)

0.16

Shock from other etiology

6 (13.3)

5 (17.9)

0.73

5 (9.2)

8 (21.6)

0.1

Bacteremia

4 (8.8)

3 (14.3)

1

6 (11.1)

5 (13.5)

0.75

Platelet count (1000/mm3)

245 ± 155

201 ± 159

0.11

291 ± 177

253 ± 164

0.27

pH

7.36 ± 0.1

7.29 ± 0.12

0.02

7.34 ± 0.11

7.3 ± 0.12

0.15

Lactate (meq/l)

1.7 ± 1.1

2.2 ± 1.8

0.43

2.6 ± 1.6

3.4 ± 3.9

0.77

Serum urea (g/l)

0.43 ± 0.3

0.41 ± 0.31

0.68

0.58 ± 0.42

0.63 ± 0.4

0.4

Creatinine (mg/l)

9.9 ± 3.7

10.1 ± 5.9

0.49

12.5 ± 5

13.6 ± 4.8

0.42

PaO2/FiO2

258 ± 111

202 ± 131

0.04

201 ± 87

193 ± 99

0.6

  1. ACE, angiotensin-converting-enzyme; ARB, angiotensin-II receptor blockers; COPD, chronic obstructive pulmonary disease; FiO2, fraction of inspired oxygen; HES, hydroxyethylstarch; NSAIDs, non-steroidal anti-inflammatory drugs; PaO2, partial pressure of arterial oxygen; RIFLE, Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function and End-stage kidney disease; SAPS, simplify acute physiology score; SD, standard deviation; SIRS, systemic inflammatory reaction syndrome; SOFA, sepsis related organ failure assessment score.
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