Effect of different components of triple-H therapy on cerebral perfusion in patients with aneurysmal subarachnoid haemorrhage: a systematic review

Dankbaar, Jan W; Slooter, Arjen JC; Rinkel, Gabriel JE; Schaaf, Irene C vander

doi:10.1186/cc8886

Critical Care

Table 1 Study design and population characteristics:

From: Effect of different components of triple-H therapy on cerebral perfusion in patients with aneurysmal subarachnoid haemorrhage: a systematic review

Reference	Study design
	Intervention type	Prophylactic/Therapeutic	Prospective	Consecutive series	Randomized	Control group
Ekelund, 2002 [18]	isovolemic hemodilution or hypervolemic hemodilution	Therapeutic	+	unknown	-	-
Mori, 1995 [14]	hypervolemic hemodilution	Therapeutic	+	unknown	-	+
Yamakami, 1987 [21]	hypervolemia	Prophylactic	+	unknown	-	-
Lennihan, 2000 [13]	hypervolemia	Prophylactic	+	+	+	+
Tseng, 2003 [23]	hypervolemia	Therapeutic	+	unknown	-	-
Jost, 2005 [22]	hypervolemia	Therapeutic	+	-	-	-
Muizelaar, 1986 [25]	hypertension	Therapeutic	unknown	-	-	-
Touho, 1992 [20]	hypertension	Both	unknown	unknown	-	-
Darby, 1994 [24]	hypertension	Therapeutic	-	-	-	-
Origitano, 1990 [15]	Triple-H	Prophylactic	+	+	-	-
Muench, 2007 [19]	Triple-H or hypertension or hypervolemic hemodilution	Prophylactic	+	unknown	-	-
*Reference*	*Population Characteristics*
	*Nr. Int/noInt*	*Mean age*	*Men*	*Clinical condition on admission: Type, median Int/no Int (range)*	*Good Recovery or moderate Disability: Int/no Int*	*Severe Disability or death: Int/no Int*
Ekelund, 2002 [18]	8/0	42	13%	H&H, 2 (1 to 3)	100%	0%
Mori, 1995 [14]	51/47	56	38%	H&H, 2/2 (1 to 4)	82%/unknown	18%/unknown
Yamakami, 1987 [21]	35/0	51	31%	H&H, ? (1 to 4)	86%	14%
Lennihan, 2000 [13]	41/41	48.5	41%	H&H, 2/2 (1 to 4)	80%/76%	17%/20%
Tseng, 2003 [23]	6/0	50	unknown	WFNS, ? (4 to 5)	unknown	unknown
Jost, 2005 [22]	6/0	49	50%	unknown	unknown	unknown
Muizelaar, 1986 [25]	4/0	44	0%	H&H, 4 (2 to 5)	100%	0%
Touho, 1992 [20]	20/0	55	55%	H&H, 2 (2 to 4)	90%	10%
Darby, 1994 [24]	13/0	59	23%	H&H, 2.5 (1 to 5)	unknown	unknown
Origitano, 1990 [15]	43/0	46	35%	H&H, 2 (1 to 4)	84%	16%
Muench, 2007 [19]	10/0	53	20%	H&H, ? (2 to 5)	unknown	unknown

DCI, delayed cerebral ischemia; H&H, Hunt and Hess grading scale for subarachnoid hemorrhage [10]; Int, Intervention; WFNS, World Federation of Neurological Surgeons score [11]

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