Table 1 Summary of published computer-assisted glucose regulation protocols, designed for critically ill patients
Reference | N | Patient type | APACHE II | Target range (mmol/L) | Performance | Hypoglycaemiaa | Measurements per patient per day |
|---|---|---|---|---|---|---|---|
Boord et al. [21] | 204 | Surgical ICU | ? | 4.4 to 6.1 | 49% of time in range | 0.2% <2.2 mmol/L | ~18 (12 to 24)b |
Cordingley et al. [22] | 16 | Mixed ICU | 16.6 | 4.4 to 6.1 | 63% of time in range | 0 <2.2 mmol/L | 10.9 |
Davidson et al. [23] | 5,808 | General medical and surgical floors | ? | Variable | 'Stable glucose' | 0.6% <2.8 mmol/L | ~18 (12 to 24)b |
Dortch et al. [24] | 243 | Trauma ICU | ISS 27.5 | 4.4 to 6.1 | 42% of measurements in range | 0.2% <2.2 mmol/L | 10.7 |
Hermayer et al. [25] | 66 | CABG | ? | 4.4 to 6.7 | Mean BG 6.4 mmol/L | 0.10% <2.2 mmol/L | 16.2c |
Horovorka et al. [26] | 30 | Cardiac surgery | ? | 4.4 to 6.1 | 60% of time in range | 0 <2.9 mmol/L | 16 |
Juneja et al. [27] | 2,398 | Mixed ICU | ? | 4.4 to 6.1 | 61% of measurements in range | 0.4% <2.8 mmol/L | ~18 (12 to 24)b |
Laha et al. [28] | 661 | Mixed ICU | 16 | 4.5 to 7.2 | 95% of measurements in the range 3.7 to 12.1 mmol/L | 1.7% of patients with a single episode <2.2 mmol/L | ~12 (6 to 24)d |
Meyenaar et al. [29] | 179 | Mixed ICU | 13 | 4.5 to 7.5 | 53% of time in range | 0.05% <2.2 mmol/L | 3.4 |
Morris et al. [30] | 775 | Mixed ICU | 21.8 | 4.4 to 6.1 | 42% of measurements in range | 0.33% <2.2 mmol/L | ~12 (6 to 24)d |
NICE-SUGAR [13]: | 3,054 | Mixed ICU | 21.1 | 4.5 to 6.0 | Mean time-weighted BG | 6.8% <2.2 mmol/L | ~12 (6 to 24)d |
intensive control | Â | Â | Â | Â | 6.4 mmol/L | Â | Â |
NICE-SUGAR [13]: conventional control | 3,050 | Mixed ICU | 21.1 | 8.0 to 10.0 | Mean time-weighted BG 8.0 mmol/L | 0.5% <2.2 mmol/L | ~12 (6 to 24)d |
Pachler et al. [31] | 25 | Medical ICU | 26.6 | 4.4 to 6.1 | HGI = 0.4 mmol/L | 1 episode <2.2 mmol/L | 12.3 |
Plank et al. [32] | 30 | Cardiac surgery | 11.4 | 4.4 to 6.1 | 52% of time in range | 0 <2.2 mmol/L | 24 |
Rood et al. [33] | 66 | Mixed ICU | 19.5 | 4.0 to 7.0 | 54% of time in range | 0.09% of time <2.5 mmol/L | 9.9c |
Saager et al. [34] | 20 | Cardiac surgery | ? | 5.0 to 8.3 | 84% of time in range | 5 episodes <3.3 mmol/L | 24 |
Shulman et al. [35] | 50 | Mixed ICU | 23 | 4.4 to 6.1 | 23% of time in range | 0.04% of time <2.2 mmol/L | 12.7 |
Thomas et al. [36] | 603 | Mixed ICU | 14.4 | 5.4 to 7.1 | 85% of measurements <8 mmol/L | 19 episodes | ~12 (6 to 24)d |
Toschlog et al. [37] | 128 | Trauma | ISS 24.5 | 4.4 to 7.2 | Mean BG 6.4 mmol/L | 32% of patients with a single episode <2.8 mmol/L | ? |
Vogelzang et al. [38] | 2,800 | Mixed ICU | 14 | 4.0 to 7.5 | 67% of time in range | 0.04% <2.2 mmol/L | 5.9 |