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Table 3 Oxygenation profile, acid-base variables and hemoglobin concentrations

From: Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study

 

Baseline

12 hours

24 hours

36 hours

48 hours

PH

(-log10 c(H+))

     

TP

7.31 ± 0.1

7.32 ± 0.1

7.32 ± 0.1

7.34 ± 0.08

7.37 ± 0.08*

AVP

7.36 ± 0.09

7.35 ± 0.11

7.32 ± 0.12

7.34 ± 0.12

7.32 ± 0.11

NE

7.34 ± 0.1

7.34 ± 0.08

7.32 ± 0.08

7.31 ± 0.09

7.28 ± 0.12*†

PaO 2 /FiO 2

     

TP

176 ± 105

179 ± 82

189 ± 86

216 ± 95

220 ± 78

AVP

219 ± 118

231 ± 117

222 ± 129

211 ± 132

225 ± 133

NE

200 ± 97

216 ± 113

213 ± 101

194 ± 73

185 ± 85

PaO 2

(mmHg)

     

TP

113 ± 44

127 ± 45

141 ± 47

164 ± 66

175 ± 64

AVP

123 ± 36

140 ± 48

130 ± 49

127 ± 59

139 ± 58

NE

120 ± 46

124 ± 44

125 ± 31

123 ± 34

114 ± 49

pvO 2

(mmHg)

     

TP

36 ± 6

36 ± 6

36 ± 5

35 ± 5

36 ± 5

AVP

35 ± 6

38 ± 6

38 ± 5

38 ± 6

38 ± 6

NE

36 ± 7

38 ± 6

38 ± 6

39 ± 7

38 ± 6

SaO 2

(%)

     

TP

96 ± 4

97 ± 3

98 ± 2

99 ± 2

99 ± 2

AVP

97 ± 3

98 ± 3

98 ± 2

96 ± 4

98 ± 2

NE

97 ± 2

96 ± 7

98 ± 1

98 ± 2

96 ± 7

SvO 2

(%)

     

TP

60 ± 7

59 ± 11

60 ± 9

60 ± 8

63 ± 8

AVP

61 ± 12

65 ± 11

64 ± 7

63 ± 13

64 ± 12

NE

62 ± 10

66 ± 10

66 ± 9

66 ± 9

62 ± 12

DO 2 I

(mL/min/m)

     

TP

473 ± 105

468 ± 117

433 ± 92

393 ± 73

402 ± 70

AVP

464 ± 137

519 ± 189

550 ± 165

484 ± 123

520 ± 242

NE

460 ± 131

471 ± 157

482 ± 136

462 ± 136

467 ± 162

VO 2 I

(mL/min/m)

     

TP

184 ± 58

184 ± 49

171 ± 32

160 ± 43

152 ± 38

AVP

173 ± 51

173 ± 59

193 ± 65

168 ± 52

173 ± 51

NE

163 ± 41

147 ± 35

160 ± 57

153 ± 51

164 ± 67

O 2 -ER

(%)

     

TP

38 ± 6

40 ± 9

40 ± 8

41 ± 8

38 ± 8

AVP

39 ± 12

35 ± 9

35 ± 6

36 ± 11

37 ± 10

NE

37 ± 10

32 ± 6

34 ± 9

34 ± 9

36 ± 10

PaCO 2

(mmHg)

     

TP

45 ± 6

42 ± 6

41 ± 9

40 ± 8

38 ± 6

AVP

43 ± 9

40 ± 5

42 ± 4

41 ± 6

41 ± 6

NE

44 ± 9

43 ± 9

44 ± 8

44 ± 8

43 ± 9

ABE

(mmol/L)

     

TP

-2.9 ± 5.1

-4.6 ± 4.2

-4.9 ± 4.6

-4.0 ± 4.2

-3.1 ± 4.2

AVP

-1.8 ± 6.5

-2.8 ± 7.0

-3.7 ± 6.7

-1.6 ± 7.8

-4.1 ± 6.5

NE

-2.5 ± 4.5

-2.5 ± 4.3

-3.5 ± 4.3

-4.2 ± 3.9

-6.2 ± 5.4*

Arterial lactate

(mmol/L)

     

TP

3.1 ± 1.8

2.9 ± 1.9

2.9 ± 2.0

3.4 ± 2.4

3.6 ± 3.0

AVP

3.0 ± 2.4

3.2 ± 2.3

3.4 ± 2.3

3.2 ± 2.3

3.4 ± 3.3

NE

3.1 ± 2.2

3.3 ± 2.8

3.4 ± 2.8

3.6 ± 2.4

4.3 ± 3.4*

Hemoglobin

(g/dL)

     

TP

8.6 ± 0.9

8.7 ± 0.7

8.4 ± 1.2

8.2 ± 0.6‡

8.1 ± 0.6

AVP

8.3 ± 0.9

8.7 ± 1.1

9 ± 1.1*

9 ± 1*†

8.8 ± 0.9

NE

8.3 ± 0.8

8.7 ± 0.9

8.4 ± 0.5

8.5 ± 0.8

8.9 ± 1

  1. ABE = arterial base excess; AVP = arginine vasopressin; DO2I = oxygen delivery index; NE = norepinephrine; O2-ER = oxygen extraction rate; PaCO2 = partial pressure of arterial carbon dioxide; PaO2/FiO2 = ratio of oxygen tension over inspired oxygen concentration; PaO2 = partial pressure of arterial oxygen; pH = arterial pH; pvO2 = mixed venous oxygen tension; SaO2 = arterial oxygen saturation; SvO2 = mixed venous oxygen saturation; VO2I = oxygen consumption index; TP = terlipressin.
  2. * P < 0.05 vs. baseline (significant time effect); † P < 0.05 vs. TP (significant group effect); ‡ P < 0.05 vs. AVP (significant group effect); § P < 0.05 vs. NE (significant group effect).
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Critical Care

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