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Figure 1 | Critical Care

Figure 1

From: Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice

Figure 1

Cardiac function as assessed by 2D ECHO at baseline and following I/R of the LAD. The baseline (normal) left ventricular ejection fraction (LVEF) obtained from 2D short axis M-mode left ventricular internal diameter trace was 67.52 ± 1.8%, 63.48 ± 2.9%, and 65.47 ± 2.4% in arginine vasopressin (AVP; n = 14), normal saline solution (SL; n = 9), and dobutamine (DOB; n = 6), resepctively. Following ischemia/reperfusion (I/R) injury, AVP treatment significantly reduced day 1 LVEF (41.1 ± 3.4%) in comparison with SL control (51.6 ± 4.3%), while both group had significant reductions in LVEF vs baseline. DOB mitigated the decrease in LVEF (57.7 ± 6.7%) day 1 post I/R. LVEF measured at day 3 demonstrated improvement in all groups; however, mice receiving AVP remained significantly lower than baseline. * P < 0.05 vs baseline, ** P < 0.05 vs SL-treated mice. Results are present as means ± standard error of the mean. LAD = left anterior descending coronary artery.

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Critical Care

ISSN: 1364-8535