0 hour | 1 hour | 2 hours | 4 hours | 6 hours | |
---|---|---|---|---|---|
PAP, mmHg | |||||
Sham | 15 ± 1 | 16 ± 1 | 16 ± 1 | 17 ± 1 | 17 ± 1 |
LPS | 18 ± 0 | 46 ± 2a | 32 ± 2a | 35 ± 2a | 33 ± 2a |
LPS+inhAPC | 17 ± 0 | 47 ± 2a | 30 ± 1a | 31 ± 1a | 29 ± 1a |
PAOP, mmHg | |||||
Sham | 7 ± 1 | 7 ± 1 | 8 ± 1 | 8 ± 1 | 7 ± 1 |
LPS | 9 ± 1 | 13 ± 1a | 12 ± 1a | 14 ± 1ab | 14 ± 1ab |
LPS+inhAPC | 9 ± 1 | 14 ± 1a | 11 ± 1a | 13 ± 1a | 12 ± 1a |
Pmo, mmHg | |||||
Sham | 6 ± 1 | 7 ± 1 | 7 ± 1 | 7 ± 1 | |
LPS | 9 ± 0 | 13 ± 1a | 14 ± 1a | 15 ± 1a | |
LPS+inhAPC | 9 ± 1 | 13 ± 1 | 12 ± 1a | 12 ± 1 | |
PVRI, dyne·sec/cm5/m2 | |||||
Sham | 144 ± 18 | 151 ± 25 | 156 ± 35 | 173 ± 26 | 191 ± 18 |
LPS | 179 ± 12 | 665 ± 107a | 353 ± 49a | 433 ± 64a | 339 ± 56a |
LPS+inhAPC | 165 ± 16 | 563 ± 63a | 351 ± 31a | 379 ± 37a | 350 ± 33a |
HR, beats/min | |||||
Sham | 102 ± 6 | 111 ± 6 | 111 ± 6 | 107 ± 7 | 100 ± 8 |
LPS | 100 ± 9 | 142 ± 15a | 154 ± 11a | 131 ± 10ab | 140 ± 5a |
LPS+inhAPC | 93 ± 10 | 160 ± 16a | 160 ± 15a | 121 ± 4ab | 128 ± 6ab |
CI, L/min/m2 | |||||
Sham | 4.5 ± 0.4 | 4.6 ± 0.4 | 4.1 ± 0.2 | 4.2 ± 0.3 | 4.3 ± 0.3 |
LPS | 4.0 ± 0.3 | 5.0 ± 0.9 | 4.8 ± 0.3 | 4.6 ± 0.6 | 4.6 ± 0.4 |
LPS+inhAPC | 4.2 ± 0.3 | 5.3 ± 0.7 | 4.7 ± 0.3 | 4.1 ± 0.2 | 4.2 ± 0.4 |
MAP, mmHg | |||||
Sham | 112 ± 5 | 118 ± 6 | 118 ± 6 | 116 ± 5 | 112 ± 6 |
LPS | 108 ± 6 | 102 ± 6 | 96 ± 6 | 103 ± 6 | 93 ± 5 |
LPS+inhAPC | 110 ± 6 | 110 ± 4 | 102 ± 5 | 111 ± 8 | 108 ± 9 |
SVRI, dyne·sec/cm5/m2 | |||||
Sham | 2068 ± 230 | 2146 ± 234 | 2261 ± 179 | 2251 ± 207 | 2139 ± 226 |
LPS | 2159 ± 179 | 2003 ± 466 | 1577 ± 146 | 1824 ± 243 | 1499 ± 154a |
LPS+inhAPC | 2151 ± 174 | 1849 ± 245 | 1839 ± 179 | 2188 ± 249 | 2130 ± 290 |
RAP, mmHg | |||||
Sham | 2 ± 1 | 3 ± 1 | 3 ± 1 | 3 ± 1 | 3 ± 1 |
LPS | 5 ± 1 | 5 ± 1 | 5 ± 1 | 9 ± 1ab | 10 ± 1ab |
LPS+inhAPC | 3 ± 0 | 3 ± 1 | 3 ± 1 | 6 ± 1ab | 8 ± 1ab |
LVSWI, g·m/m2 | |||||
Sham | 63 ± 4 | 72 ± 9 | 56 ± 4 | 58 ± 6 | 60 ± 6 |
LPS | 52 ± 7 | 42 ± 6 | 36 ± 5a | 39 ± 3 | 33 ± 3a |
LPS+inhAPC | 66 ± 6 | 42 ± 4 | 36 ± 4a | 43 ± 3a | 41 ± 4a |
RVSWI, g·m/m2 | |||||
Sham | 7 ± 1 | 9 ± 2 | 6 ± 1 | 8 ± 1 | 8 ± 2 |
LPS | 7 ± 1 | 19 ± 3a | 11 ± 1a | 11 ± 1a | 9 ± 1a |
LPS+inhAPC | 9 ± 1 | 19 ± 2 | 11 ± 1 | 12 ± 1 | 10 ± 1 |
EVLWI, mL/kg | |||||
Sham | 10 ± 1 | 10 ± 0 | 10 ± 0 | 10 ± 0 | |
LPS | 10 ± 1 | 11 ± 1 | 11 ± 0 | 12 ± 1a | |
LPS+inhAPC | 9 ± 0 | 11 ± 1a | 10 ± 1 | 11 ± 1a |