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Table 2 Effects of inhaled activated protein C on lipopolysaccharide-induced changes in systemic and pulmonary haemodynamic variables in sheep.

From: Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin-induced lung injury in anaesthetised sheep

 

0 hour

1 hour

2 hours

4 hours

6 hours

PAP, mmHg

     

   Sham

15 ± 1

16 ± 1

16 ± 1

17 ± 1

17 ± 1

   LPS

18 ± 0

46 ± 2a

32 ± 2a

35 ± 2a

33 ± 2a

   LPS+inhAPC

17 ± 0

47 ± 2a

30 ± 1a

31 ± 1a

29 ± 1a

PAOP, mmHg

     

   Sham

7 ± 1

7 ± 1

8 ± 1

8 ± 1

7 ± 1

   LPS

9 ± 1

13 ± 1a

12 ± 1a

14 ± 1ab

14 ± 1ab

   LPS+inhAPC

9 ± 1

14 ± 1a

11 ± 1a

13 ± 1a

12 ± 1a

Pmo, mmHg

     

   Sham

6 ± 1

 

7 ± 1

7 ± 1

7 ± 1

   LPS

9 ± 0

 

13 ± 1a

14 ± 1a

15 ± 1a

   LPS+inhAPC

9 ± 1

 

13 ± 1

12 ± 1a

12 ± 1

PVRI, dyne·sec/cm5/m2

     

   Sham

144 ± 18

151 ± 25

156 ± 35

173 ± 26

191 ± 18

   LPS

179 ± 12

665 ± 107a

353 ± 49a

433 ± 64a

339 ± 56a

   LPS+inhAPC

165 ± 16

563 ± 63a

351 ± 31a

379 ± 37a

350 ± 33a

HR, beats/min

     

   Sham

102 ± 6

111 ± 6

111 ± 6

107 ± 7

100 ± 8

   LPS

100 ± 9

142 ± 15a

154 ± 11a

131 ± 10ab

140 ± 5a

   LPS+inhAPC

93 ± 10

160 ± 16a

160 ± 15a

121 ± 4ab

128 ± 6ab

CI, L/min/m2

     

   Sham

4.5 ± 0.4

4.6 ± 0.4

4.1 ± 0.2

4.2 ± 0.3

4.3 ± 0.3

   LPS

4.0 ± 0.3

5.0 ± 0.9

4.8 ± 0.3

4.6 ± 0.6

4.6 ± 0.4

   LPS+inhAPC

4.2 ± 0.3

5.3 ± 0.7

4.7 ± 0.3

4.1 ± 0.2

4.2 ± 0.4

MAP, mmHg

     

   Sham

112 ± 5

118 ± 6

118 ± 6

116 ± 5

112 ± 6

   LPS

108 ± 6

102 ± 6

96 ± 6

103 ± 6

93 ± 5

   LPS+inhAPC

110 ± 6

110 ± 4

102 ± 5

111 ± 8

108 ± 9

SVRI, dyne·sec/cm5/m2

     

   Sham

2068 ± 230

2146 ± 234

2261 ± 179

2251 ± 207

2139 ± 226

   LPS

2159 ± 179

2003 ± 466

1577 ± 146

1824 ± 243

1499 ± 154a

   LPS+inhAPC

2151 ± 174

1849 ± 245

1839 ± 179

2188 ± 249

2130 ± 290

RAP, mmHg

     

   Sham

2 ± 1

3 ± 1

3 ± 1

3 ± 1

3 ± 1

   LPS

5 ± 1

5 ± 1

5 ± 1

9 ± 1ab

10 ± 1ab

   LPS+inhAPC

3 ± 0

3 ± 1

3 ± 1

6 ± 1ab

8 ± 1ab

LVSWI, g·m/m2

     

   Sham

63 ± 4

72 ± 9

56 ± 4

58 ± 6

60 ± 6

   LPS

52 ± 7

42 ± 6

36 ± 5a

39 ± 3

33 ± 3a

   LPS+inhAPC

66 ± 6

42 ± 4

36 ± 4a

43 ± 3a

41 ± 4a

RVSWI, g·m/m2

     

   Sham

7 ± 1

9 ± 2

6 ± 1

8 ± 1

8 ± 2

   LPS

7 ± 1

19 ± 3a

11 ± 1a

11 ± 1a

9 ± 1a

   LPS+inhAPC

9 ± 1

19 ± 2

11 ± 1

12 ± 1

10 ± 1

EVLWI, mL/kg

     

   Sham

10 ± 1

 

10 ± 0

10 ± 0

10 ± 0

   LPS

10 ± 1

 

11 ± 1

11 ± 0

12 ± 1a

   LPS+inhAPC

9 ± 0

 

11 ± 1a

10 ± 1

11 ± 1a

  1. Data presented as the mean ± standard error of the mean.
  2. CI = cardiac index; EVLWI = extravascular lung water index; HR = heart rate; LPS = sheep receiving infusion of lipopolysaccharide (n = 8); LPS+inhAPC = sheep receiving LPS and inhaled nebulised recombinant human activated protein C (n = 8); LVSWI = left ventricle stroke work index; MAP = mean systemic arterial pressure; PAP = pulmonary artery pressure; PAOP = pulmonary artery occlusion pressure; Pmo = pulmonary micro occlusion pressure; PVRI = pulmonary vascular resistance index; RAP = right atrial pressure; RVSWI = right ventricle stroke work index;Sham = sham operated sheep (n = 8); SVRI = systemic vascular resistance index.
  3. aP < 0.05 from t = 0 hours; bP < 0.05 from t = 2 hours.