0 hour | 2 hours | 4 hours | 6 hours | |
---|---|---|---|---|
SaO2, % | ||||
Sham | 97 ± 1 | 98 ± 0 | 98 ± 1 | 98 ± 1 |
LPS | 97 ± 1 | 86 ± 3a | 84 ± 3a | 84 ± 4a |
LPS+inhAPC | 98 ± 1 | 86 ± 3a | 93 ± 2ab | 94 ± 1ab |
SvO2, % | ||||
Sham | 68 ± 2 | 69 ± 2 | 68 ± 2 | 67 ± 2 |
LPS | 64 ± 2 | 58 ± 4 | 51 ± 4a | 54 ± 5a |
LPS+inhAPC | 68 ± 2 | 58 ± 3a | 65 ± 3bc | 64 ± 4b |
Temp, C° | ||||
Sham | 38.1 ± 0.3 | 38.4 ± 0.4 | 38.8 ± 0.4ab | 38.8 ± 0.4ab |
LPS | 38.3 ± 0.3 | 39.4 ± 0.3a | 40.2 ± 0.2ab | 40.4 ± 0.3ab |
LPS+inhAPC | 38.3 ± 0.1 | 39.4 ± 0.1a | 40.3 ± 0.1ab | 40.5 ± 0.1ab |
Hb, g/dL | ||||
Sham | 8 ± 0 | 9 ± 0 | 9 ± 0 | 8 ± 0 |
LPS | 9 ± 1 | 11 ± 1a | 11 ± 1a | 11 ± 1a |
LPS+inhAPC | 9 ± 0 | 12 ± 0a | 12 ± 0a | 11 ± 0a |
pH | ||||
Sham | 7.53 ± 0.01 | 7.54 ± 0.01 | 7.56 ± 0.01 | 7.53 ± 0.01 |
LPS | 7.52 ± 0.01 | 7.51 ± 0.02 | 7.51 ± 0.02 | 7.52 ± 0.02 |
LPS+inhAPC | 7.51 ± 0.01 | 7.48 ± 0.02 | 7.53 ± 0.02bc | 7.54 ± 0.01ab |
PaCO2 | ||||
Sham | 37 ± 2 | 36 ± 2 | 35 ± 1 | 34 ± 2 |
LPS | 40 ± 2 | 41 ± 2 | 41 ± 2 | 39 ± 2 |
LPS+APC | 40 ± 1 | 42 ± 3 | 37 ± 2b | 37 ± 1b |