Parameter | Group | T0 h | T2 h | T5 h | Â |
---|---|---|---|---|---|
Mean arterial pressure (mmHg) | Controls | 125 ± 4 | 64 ± 7 | 59 ± 6 |  |
 | Bosentan | 141 ± 7 | 73 ± 5 | 61 ± 6 |  |
Mean pulmonary artery pressure (mmHg) | Controls |   28 ± 2 | 35 ± 2 | 34 ± 2 | *** |
 | Bosentan |   27 ± 2 | 34 ± 2 | 20 ± 1 |  |
Pulmonary vascular resistance index (mmHg kg min/ml) | Controls |   182 ± 23 | 349 ± 52 | 398 ± 68 | *** |
 | Bosentan |   155 ± 29 | 262 ± 47 |   97 ± 19 |  |
Cardiac index (ml/min/kg) | Controls | 111 ± 5 | 74 ± 6 | 65 ± 8 | ** |
 | Bosentan |   130 ± 13 |   85 ± 10 | 130 ± 16 |  |
Stroke volume index (ml/beat/kg) | Controls |     0.71 ± 0.07 |   0.43 ± 0.04 |   0.34 ± 0.06 | * |
 | Bosentan |     0.87 ± 0.13 |   0.52 ± 0.09 |   0.69 ± 0.09 |  |
Systemic vascular resistance index (mmHg kg min/ml) | Controls | 1100 ± 56 |   830 ± 100 | 840 ± 69 | ** |
 | Bosentan |   1100 ± 120 |   870 ± 100 | 450 ± 66 |  |
Oxygen delivery index (ml/min/kg) | Controls |   18 ± 1 | 13 ± 1 | 11 ± 1 | ** |
 | Bosentan |   19 ± 2 | 13 ± 1 | 18 ± 2 |  |