Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep

Table 3 Lung injury score in instrumented awake sheep

Variable	Edema	Neutrophil infiltration	Hemorrhage	Epithelial desquamation	Hyaline membranes	Lung injury score
rhAPC	1.3 (1.0 to 2.0)	0.5 (0.0 to 2.0)	1.0 (0.0 to 3.0)	0.5 (0.0 to 1.0)	0.0 (0.0 to 1.0)	3.8 (2.0 to 6.5)
LPS	2.0 (1.0 to 3.0)	2.5 (0.5 to 3.5)*	0.8 (0.0 to 2.0)	1.0 (0.5 to 4.0)*	1.0 (0.0 to 2.0)*	6.8 (2.5 to 11.5)*
LPS + rhAPC	1.0 (0.5 to 2.0)^†	1.0 (0.0 to 2.0)^†	1.0 (0.0 to 2.0)	1.0 (0.5 to 2.0)	0.5 (0.0 to 2.0)	4.5 (1.5 to 8.5)^†

Data presented as the median (minimum to maximum). rhAPC, recombinant human activated protein C alone group (n = 4); LPS, lipopolysaccharide group (n = 8); LPS + rhAPC, rhAPC-treated LPS group (n = 9). The histological markers of lung injury are scored on a scale from zero to four. *P < 0.05 between the LPS and the rhAPC groups. ^†P < 0.05 between the LPS and the LPS + rhAPC groups.

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